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LEGACy SIGNED

CeLac and European consortium for a personalized medicine approach to Gastric Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 LEGACy project word cloud

Explore the words cloud of the LEGACy project. It provides you a very rough idea of what is the project "LEGACy" about.

omics    strategies    epstein    susceptibility    incidence    levels    vary    personalized    similarly    death    revolutionized    rates    celac    barr    prognosis    legacy    lowest    outcomes    multicentre    ebv    723    deaths    primary    infection    america    poorly    positive    molecular    disease    strains    epidemiology    genome    extended    locally    epidemiological    men    24    pylori       virus    globally    location    secondary    stage    urgent    women    integrative    biology    dietary    participating    health    strategy    plays    arrival    multiple    patients    sexes    total    largely    treatments    countries    medicine    contrast    prevention    eastern    populations    intervention    cancer    asian    none    differences    conceptual    bacterium    10    public    mortality    standpoint    gc    databases    asia    south    central    makeup    worldwide    gastric    helicobacter    northern    tumour    histological    highest    respectively    gcs    sharp    international    model    genetic   

Project "LEGACy" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA 

Organization address
address: AV MENENDEZ PELAYO 4
city: VALENCIA
postcode: 46010
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 3˙993˙056 €
 EC max contribution 3˙577˙431 € (90%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA ES (VALENCIA) coordinator 638˙315.00
2    IPATIMUP - INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP PT (PORTO) participant 660˙162.00
3    FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON ES (BARCELONA) participant 550˙000.00
4    STICHTING VUMC NL (AMSTERDAM) participant 471˙875.00
5    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE CL (SANTIAGO) participant 305˙235.00
6    ANAXOMICS BIOTECH, S.L. ES (BARCELONA) participant 275˙218.00
7    CABALLERO LLANO CARMELO CESAR PY (ASUNCION) participant 216˙093.00
8    EUROPEAN CANCER PATIENT COALITION BE (BRUXELLES) participant 197˙750.00
9    ALEXANDER FLEMING SA AR (BUENOS AIRES) participant 131˙625.00
10    UNIVERSITAET LEIPZIG DE (LEIPZIG) participant 131˙156.00
11    Instituto Nacional de Cancerología MX (MEXICO) participant 0.00

Map

 Project objective

Globally, gastric cancer (GC) is the third leading cause of cancer death in both sexes worldwide (723,000 deaths, 8.8% of the total). The highest estimated mortality rates are in Eastern Asia (24 per 100,000 in men, 9.8 per 100,000 in women), the lowest in Northern America (2.8 and 1.5, respectively). High mortality rates are also present in both sexes in Central and Eastern Europe, and in Central and South America. None strategies have improved prognosis in locally advanced stage III and IV GC. Therefore, an urgent intervention is needed. Epidemiological and molecular features of GCs can vary widely according to their histological type, location and genetic makeup of the tumour. The reasons behind these differences are multiple and complex and may include genetic susceptibility, strains of the bacterium Helicobacter pylori (H. pylori) and dietary factors. In particular, H. pylori infection plays a relevant role in GC incidence. Similarly, about 10% of GC patients are positive for the infection of the Epstein Barr Virus (EBV) . Most studies and current international databases on late-stage/advanced GC are largely based on Asian populations, in sharp contrast tumour biology and genome of EU and CELAC countries is poorly known. From a public health standpoint, prevention can be conducted at three levels: primary, secondary, and for improving outcomes at the advanced stage of disease. In recent years, the arrival of personalized medicine has revolutionized available treatments for cancer patients. The primary aim of LEGACY project is to improve GC outcomes by applying personalized medicine at the three levels of prevention: in EU and CELAC countries participating in this multicentre case-control study based on an “omics integrative epidemiology” conceptual model as a strategy to be extended worldwide.

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The information about "LEGACY" are provided by the European Opendata Portal: CORDIS opendata.

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