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ROMB SIGNED

Retina Organoid Mechanobiology

Total Cost €

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EC-Contrib. €

0

Partnership

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 ROMB project word cloud

Explore the words cloud of the ROMB project. It provides you a very rough idea of what is the project "ROMB" about.

promises    app    gene    hallmark    behavior    carries    first    organoid    engineering    ball    interactions    model    readout    signatures    functional    recorded    prevented    alzheimer    uniquely    regulating    onset    glaucoma    establishment    variations    cells    genetic    retina    lightsheet    abnormalities    manipulate    mechanically    hereby    basic    stem    diseases    mechanics    vitro    mouse    mimic    breakthrough    actuators    aggregates    environment    neuronal    microscopy    signals    building    players    opening    organoids    reveal    ferrofluid    modeling    exists    romb    tissue    cellular    mechanobiology    mutation    me    mechanical    posts    introduces    multifaceted    guide    detect    organogenesis    final    techniques    cell    organization    door    disciplinary    biophysical    bioengineers    quantify    physiological    physicists    court    peptide    droplets    tailoring    shape    accordingly    3d    tackle    neuroscience    retinas    plan    cross    turn    linked    suited    revealed    disease    opens    quantified    limited    function    physical   

Project "ROMB" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙497˙175 €
 EC max contribution 1˙497˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙497˙175.00

Map

 Project objective

The retina carries signatures of neuronal diseases which have been linked to mechanical abnormalities, including Glaucoma and Alzheimer’s disease. Yet no biophysical retina model exists due to a cross-disciplinary challenge: While stem cell derived organoids mimic the retina in vitro, organoid research has been limited by large variations in cell and tissue organization. Mechanobiology, in turn, has revealed mechanical signals as essential players in regulating cellular behavior to guide organogenesis. Accordingly, the ball is in the court of physicists and bioengineers to quantify those mechanical signals and shape tissue growth by tailoring the physical interactions of cells with their environment. Finally, the functionality of the retina has to be quantified via neuroscience techniques. This multifaceted challenge has prevented the establishment of the retina organoid as a biophysical model. ROMB introduces a biophysical model for the retina which I will use to model Alzheimer’s disease in vitro. It will be built on 4 cross-disciplinary posts: (i) retina organoids as a physiological in vitro model, (ii) tissue mechanics measurements, (iii) neuronal activity readout and (iv) disease modeling. First, I will reveal the mechanical building plan of retina organoids using ferrofluid droplets as mechanical actuators, hereby opening the field of organoid mechanobiology. In a second step, the organoid’s 3D neuronal function will be recorded using lightsheet microscopy. Mechanical, functional and genetic access will allow me in a final step to detect and manipulate Alzheimer’s disease: using mouse retina organoids with a mutation in the App gene, I will mechanically characterize the formation of those peptide aggregates which are the hallmark of disease onset. ROMB opens the door to engineering functional retinas in vitro. Moreover, it will be uniquely suited to tackle mechanically related neuronal diseases and promises a breakthrough for basic and applied research.

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The information about "ROMB" are provided by the European Opendata Portal: CORDIS opendata.

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