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BatSECoV SIGNED

Canonical and non-canonical secretory mechanisms of cytokines in bat and human cell cultures in response to coronavirus infection: a comparative study

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BatSECoV project word cloud

Explore the words cloud of the BatSECoV project. It provides you a very rough idea of what is the project "BatSECoV" about.

antiviral    molecular    consist    insights    health    techniques    releases    canonical    wellbeing    scientific    reservoir    subjected    cytokines    transferable    congresses    multidisciplinary    lack    biology    majority    knockdowns    activation    responsible    science    ifn    ifns    societal    infections    interactions    interferons    analyzing    cell    bats    mers    line    international    bat    receptors    immune    emerged    secretion    infected    gaps    innate    serve    viruses    secretory    tolerance    demographic    community    journals    coronaviruses    strategy    combination    listed    species    skills    cells    supernatants    interleukins    sars    divulgation    publications    culture    outcome    cytokine    mechanisms    influence    strategies    details    pathology    fight    coronavirus    nature    press    peer    originally    candidate    host    context    cov    il    virology    molecules    secretions    virus    human    transfer    training    zoonotic    implicated    mechanistic    pathogenic    platform    participation    events   

Project "BatSECoV" data sheet

The following table provides information about the project.

Coordinator
CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 162˙806.00

Map

 Project objective

The majority of coronaviruses (CoV) originally emerged from bats including highly pathogenic SARS- and MERS-CoV. Bats evolved unique innate immune mechanisms that are likely responsible for the lack of immune pathology. One key process of the immune response is the secretion of cytokines, like interleukins (IL) and type I interferons (IFNs), however molecular details of cytokine secretions and their influence on the outcome of virus infections have not been studied in context of reservoir host species like bats. The aim of this research proposal is to determine the molecular mechanisms involved in the secretion of IL-1 and IFN in human and bat cells that could explain why bats have developed a tolerance against coronavirus infections. The training-through-research of the candidate will consist in analyzing the secretion of IFNs and IL-1 in cell culture supernatants of bat and human CoV-infected cells subjected to knockdowns of different molecules implicated in canonical or non-canonical secretory pathways, as well as activation and interactions between receptors of both secretory pathways. The multidisciplinary nature of the project is strong, involving a combination of well developed molecular biology, cell biology, and virology. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques and transferable skills. The results will show in-depth mechanistic insights into bat cytokine secretion, which still has some gaps in its knowledge, and will serve as a promising platform for the development of new antiviral strategies to fight emerging zoonotic viruses, in line with the EU strategy listed Societal Changes of H2020 for the health, demographic change and wellbeing. The dissemination of the results to the scientific community will be done by publications in international open-access peer-reviewed journals, congresses, press releases and participation at science divulgation events.

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The information about "BATSECOV" are provided by the European Opendata Portal: CORDIS opendata.

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