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BatSECoV SIGNED

Canonical and non-canonical secretory mechanisms of cytokines in bat and human cell cultures in response to coronavirus infection: a comparative study

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BatSECoV project word cloud

Explore the words cloud of the BatSECoV project. It provides you a very rough idea of what is the project "BatSECoV" about.

ifn    divulgation    skills    emerged    fight    molecules    coronavirus    cytokines    secretions    il    antiviral    community    wellbeing    secretion    congresses    listed    infected    events    training    cell    participation    multidisciplinary    virology    knockdowns    host    mechanisms    molecular    receptors    platform    viruses    immune    analyzing    majority    science    combination    biology    serve    journals    responsible    infections    nature    pathology    interactions    mechanistic    virus    secretory    techniques    gaps    health    press    bats    context    subjected    international    cytokine    interleukins    human    innate    zoonotic    canonical    tolerance    interferons    releases    cov    strategies    originally    candidate    supernatants    pathogenic    culture    influence    reservoir    implicated    demographic    scientific    bat    lack    activation    coronaviruses    line    sars    publications    cells    transferable    details    peer    mers    ifns    societal    insights    strategy    transfer    species    outcome    consist   

Project "BatSECoV" data sheet

The following table provides information about the project.

Coordinator
CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 162˙806.00

Map

 Project objective

The majority of coronaviruses (CoV) originally emerged from bats including highly pathogenic SARS- and MERS-CoV. Bats evolved unique innate immune mechanisms that are likely responsible for the lack of immune pathology. One key process of the immune response is the secretion of cytokines, like interleukins (IL) and type I interferons (IFNs), however molecular details of cytokine secretions and their influence on the outcome of virus infections have not been studied in context of reservoir host species like bats. The aim of this research proposal is to determine the molecular mechanisms involved in the secretion of IL-1 and IFN in human and bat cells that could explain why bats have developed a tolerance against coronavirus infections. The training-through-research of the candidate will consist in analyzing the secretion of IFNs and IL-1 in cell culture supernatants of bat and human CoV-infected cells subjected to knockdowns of different molecules implicated in canonical or non-canonical secretory pathways, as well as activation and interactions between receptors of both secretory pathways. The multidisciplinary nature of the project is strong, involving a combination of well developed molecular biology, cell biology, and virology. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques and transferable skills. The results will show in-depth mechanistic insights into bat cytokine secretion, which still has some gaps in its knowledge, and will serve as a promising platform for the development of new antiviral strategies to fight emerging zoonotic viruses, in line with the EU strategy listed Societal Changes of H2020 for the health, demographic change and wellbeing. The dissemination of the results to the scientific community will be done by publications in international open-access peer-reviewed journals, congresses, press releases and participation at science divulgation events.

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