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BatSECoV SIGNED

Canonical and non-canonical secretory mechanisms of cytokines in bat and human cell cultures in response to coronavirus infection: a comparative study

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BatSECoV project word cloud

Explore the words cloud of the BatSECoV project. It provides you a very rough idea of what is the project "BatSECoV" about.

canonical    consist    originally    training    secretion    context    peer    il    sars    responsible    interferons    outcome    listed    secretory    demographic    subjected    receptors    ifns    skills    techniques    details    line    antiviral    innate    viruses    majority    human    cell    species    infected    interleukins    pathology    wellbeing    bat    nature    coronavirus    secretions    lack    cytokines    molecules    activation    congresses    platform    zoonotic    implicated    tolerance    candidate    immune    insights    cov    events    transfer    infections    influence    biology    gaps    cytokine    serve    virus    community    press    releases    mers    molecular    mechanistic    mechanisms    divulgation    combination    transferable    emerged    bats    strategies    cells    host    journals    knockdowns    societal    reservoir    participation    interactions    multidisciplinary    fight    culture    publications    analyzing    international    coronaviruses    science    ifn    health    strategy    supernatants    virology    scientific    pathogenic   

Project "BatSECoV" data sheet

The following table provides information about the project.

Coordinator
CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 162˙806.00

Map

 Project objective

The majority of coronaviruses (CoV) originally emerged from bats including highly pathogenic SARS- and MERS-CoV. Bats evolved unique innate immune mechanisms that are likely responsible for the lack of immune pathology. One key process of the immune response is the secretion of cytokines, like interleukins (IL) and type I interferons (IFNs), however molecular details of cytokine secretions and their influence on the outcome of virus infections have not been studied in context of reservoir host species like bats. The aim of this research proposal is to determine the molecular mechanisms involved in the secretion of IL-1 and IFN in human and bat cells that could explain why bats have developed a tolerance against coronavirus infections. The training-through-research of the candidate will consist in analyzing the secretion of IFNs and IL-1 in cell culture supernatants of bat and human CoV-infected cells subjected to knockdowns of different molecules implicated in canonical or non-canonical secretory pathways, as well as activation and interactions between receptors of both secretory pathways. The multidisciplinary nature of the project is strong, involving a combination of well developed molecular biology, cell biology, and virology. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques and transferable skills. The results will show in-depth mechanistic insights into bat cytokine secretion, which still has some gaps in its knowledge, and will serve as a promising platform for the development of new antiviral strategies to fight emerging zoonotic viruses, in line with the EU strategy listed Societal Changes of H2020 for the health, demographic change and wellbeing. The dissemination of the results to the scientific community will be done by publications in international open-access peer-reviewed journals, congresses, press releases and participation at science divulgation events.

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The information about "BATSECOV" are provided by the European Opendata Portal: CORDIS opendata.

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