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SmartHeart SIGNED

SmartHeart, a 3D in vitro assay for improved assessment of cardiac drug efficacy and toxicity

Total Cost €

EC-Contrib. €

Partnership

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SmartHeart project word cloud

Explore the words cloud of the SmartHeart project. It provides you a very rough idea of what is the project "SmartHeart" about.

angle act cros drug cardiac microstructured screening transients acquired trials limiting cardiomyocytes cells currently closer vitro qualitative smartheart 3d maturity specifications compatible techniques industrial multiwell predict minimized put fine leader er career 3dcell commercial gel assays cms contractility entering culture maturation whom animal feedback answer final efficient drugs device tune sub plates cellular ethical pluripotent simultaneously ultimate proprietary academic physics platforms 6 shortcomings human assay outs 4dcell models stem structure imaging standards retrieve hts body meet stage technological commercialized action diseases mimic cultured observation managerial pharma read calcium quantitative hcs competences clinical nature expertise candidate resolution

Project "SmartHeart" data sheet

The following table provides information about the project.

Coordinator	4DCELL Organization address address: 14 RUE DE LA BEAUNE BAT C ETAGE 2 city: MONTREUIL postcode: 93100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	196˙707 €
EC max contribution	196˙707 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-EF-SE
Starting year	2020
Duration (year-month-day)	from 2020-03-02 to 2022-03-01

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	4DCELL 4DCELL Organization address address: 14 RUE DE LA BEAUNE BAT C ETAGE 2 city: MONTREUIL postcode: 93100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (MONTREUIL)	coordinator	196˙707.00

Map

Project objective

Currently, animal models are still widely used in the pre-clinical stage of drug development to mimic human diseases or predict the human body’s response to candidate drugs. However, their use should be minimized as much as possible due to ethical issues and since only 9.6% of drugs entering phase I of clinical trials end up being commercialized. Therefore, the goal of this action is to develop a novel proprietary 3D in vitro cardiac assay. The SmartHeart will retrieve several of the most important read-outs commonly assessed to study the impact of drugs at the cardiac level in the pre-clinical phase. The all in one assay will be based on a microstructured gel where cardiac cells, as cardiomyocytes derived from induced pluripotent stem cells will be cultured. The SmartHeart will answer to the shortcomings of academic and commercial available in vitro assays, by enabling the qualitative and quantitative measurement of several parameters, as contractility and Calcium transients. Simultaneously, the assay will enable sub-cellular structure observation via high-resolution imaging techniques. Furthermore, the 3D nature of the assay will contribute to the efficient maturation of the induced CMs, which is still a limiting factor when not using cardiac human cells, but rather induced CMs, in in vitro assays. The ultimate aim of the project is to make this device available to screening platforms, e.g. Pharma or CROs. The technology will be implemented in multiwell plates compatible with the standards of HTS/HCS and will be available to early-users, from whom feedback will be acquired, enabling to fine tune the specifications of the final device. This project will meet the best of the ER competences in physics, with the expertise of 4Dcell in 3Dcell culture systems. With this project, the ER will reach a level of maturity on several technological, managerial and industrial aspects providing her a new career angle and put her a step closer to act as a leader in research.

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The information about "SMARTHEART" are provided by the European Opendata Portal: CORDIS opendata.