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SmartHeart SIGNED

SmartHeart, a 3D in vitro assay for improved assessment of cardiac drug efficacy and toxicity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SmartHeart project word cloud

Explore the words cloud of the SmartHeart project. It provides you a very rough idea of what is the project "SmartHeart" about.

clinical    culture    animal    transients    quantitative    fine    plates    meet    hts    body    technological    physics    cells    maturation    maturity    standards    observation    currently    models    contractility    commercial    device    acquired    proprietary    microstructured    industrial    pluripotent    3d    screening    answer    nature    compatible    assays    read    structure    gel    calcium    put    smartheart    outs    qualitative    entering    cms    ultimate    whom    stage    hcs    specifications    assay    er    retrieve    limiting    techniques    simultaneously    predict    cultured    managerial    trials    multiwell    leader    mimic    sub    vitro    efficient    minimized    act    4dcell    action    final    expertise    cardiac       diseases    human    career    ethical    candidate    competences    pharma    cellular    angle    commercialized    drug    feedback    3dcell    cardiomyocytes    cros    stem    academic    shortcomings    tune    closer    resolution    drugs    platforms    imaging   

Project "SmartHeart" data sheet

The following table provides information about the project.

Coordinator
4DCELL 

Organization address
address: 14 RUE DE LA BEAUNE BAT C ETAGE 2
city: MONTREUIL
postcode: 93100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-03-02   to  2022-03-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    4DCELL FR (MONTREUIL) coordinator 196˙707.00

Map

 Project objective

Currently, animal models are still widely used in the pre-clinical stage of drug development to mimic human diseases or predict the human body’s response to candidate drugs. However, their use should be minimized as much as possible due to ethical issues and since only 9.6% of drugs entering phase I of clinical trials end up being commercialized. Therefore, the goal of this action is to develop a novel proprietary 3D in vitro cardiac assay. The SmartHeart will retrieve several of the most important read-outs commonly assessed to study the impact of drugs at the cardiac level in the pre-clinical phase. The all in one assay will be based on a microstructured gel where cardiac cells, as cardiomyocytes derived from induced pluripotent stem cells will be cultured. The SmartHeart will answer to the shortcomings of academic and commercial available in vitro assays, by enabling the qualitative and quantitative measurement of several parameters, as contractility and Calcium transients. Simultaneously, the assay will enable sub-cellular structure observation via high-resolution imaging techniques. Furthermore, the 3D nature of the assay will contribute to the efficient maturation of the induced CMs, which is still a limiting factor when not using cardiac human cells, but rather induced CMs, in in vitro assays. The ultimate aim of the project is to make this device available to screening platforms, e.g. Pharma or CROs. The technology will be implemented in multiwell plates compatible with the standards of HTS/HCS and will be available to early-users, from whom feedback will be acquired, enabling to fine tune the specifications of the final device. This project will meet the best of the ER competences in physics, with the expertise of 4Dcell in 3Dcell culture systems. With this project, the ER will reach a level of maturity on several technological, managerial and industrial aspects providing her a new career angle and put her a step closer to act as a leader in research.

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The information about "SMARTHEART" are provided by the European Opendata Portal: CORDIS opendata.

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