Opendata, web and dolomites

FluAttack SIGNED

Validation of a novel antiviral drug candidate against influenza

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FluAttack project word cloud

Explore the words cloud of the FluAttack project. It provides you a very rough idea of what is the project "FluAttack" about.

prevent    replication    molecule    limitations    mouse    agent    risk    creation    start    characterise    tests    health    lt    hit    potent    lab    cells    extremely    specialists    demand    repurposing    secure    burden    influenza    compounds    action    heavy    infection    vivo    family    rely    trials    mode    data    pathogens    with    devastating    powerful    function    advantage    virus    economic    cellular    validate    went    deaths    severe    screening    molecules    escape    agree    resistance    stg    pandemic    inhibitors    commercial    viruses    airway    clinical    erc    reduce    limited    organization    pandemics    world    ipr    preclinical    worldwide    societies    hits    actually    model    preventing    3d    innovative    million    poc    time    treat    vaccination    few    respect    lives    strategy    ic50    approved    patent    perfect    solutions    licensing    infections    options    100nm    epithelial    cancer    context    human    efficacy    candidate    solution    antivir    drug    therapeutic    urgently    predicted    plan    anti    viral    650   

Project "FluAttack" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 139˙081.00
2    CNRS INNOVATION FR (PARIS) participant 10˙919.00

Map

 Project objective

With 3 to 5 million severe cases and up to 650,000 deaths per year worldwide, influenza viruses are not only major human pathogens, they are also a heavy economic burden to our societies. In addition, influenza pandemics can occur at any time with potential devastating effects in terms of lives and costs. Solutions to prevent infection, to treat severe influenza cases and to respond to a severe pandemic are currently extremely limited and rely on vaccination and on only few approved molecules. All these solutions have their limitations with respect to efficacy and all face the problem of viral resistance. Thus, the demand for new options against influenza infections is high. The World Health Organization (WHO) and influenza virus specialists agree that innovative and effective anti-influenza compounds with a reduced risk of viral escape are urgently needed. The main goal of this ERC PoC is to provide key data on a promising innovative therapeutic solution identified in the lab. Taking advantage of a powerful screening system we have developed during the ERC StG ANTIViR, we have identified a family of molecules as potent inhibitors of influenza virus (with IC50<100nM). The mode of action of these molecules is known and they actually target a cellular function essential to all influenza viruses. Preventing viral replication by targeting a cellular function is a novel approach, predicted to strongly reduce the risk of drug resistance. Importantly, one of our hits went through several phase II and III clinical trials as an anti-cancer agent, making this molecule a perfect candidate for drug repurposing. In this context, the specific objectives of this ERC PoC are: i) to further characterise and validate our best hit, in particular in commercial 3D human airway epithelial cells and in vivo in a mouse model, and ii) to secure IPR and to establish an exploitation strategy plan (patent licensing or creation of a start-up) to support future development and preclinical tests.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FLUATTACK" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FLUATTACK" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HyperBio (2019)

Vis-NIR Hyperspectral imaging for biomaterial quality control

Read More  

EASY-IPS (2019)

a rapid and efficient method for generation of iPSC

Read More  

CHIPTRANSFORM (2018)

On-chip optical communication with transformation optics

Read More