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miRanDa SIGNED

microRNA assay system based on self-assembled nanoscale DNA origami arrays

Total Cost €

EC-Contrib. €

Partnership

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miRanDa project word cloud

Explore the words cloud of the miRanDa project. It provides you a very rough idea of what is the project "miRanDa" about.

consumption nucleic quantification nanoscale miranda mirna absolute monitoring cancer additional resolution structures relevance arrays diagnosis species lack clinical lncrna amplification dna biomarkers treatment rapid techniques self lattices breast hybridization mrna prognosis paint limited sensitive time sticky micrornas technique assembled simultaneous ctdna multiple progression acid 2d cells multiplexing plasma super detection origami capacity assay finite mirnas configured

Project "miRanDa" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE DE FRIBOURG Organization address address: AVENUE DE L EUROPE 20 city: FRIBOURG postcode: 1700 website: www.unifr.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	203˙149 €
EC max contribution	203˙149 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-EF-ST
Starting year	2021
Duration (year-month-day)	from 2021-06-01 to 2023-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE DE FRIBOURG UNIVERSITE DE FRIBOURG Organization address address: AVENUE DE L EUROPE 20 city: FRIBOURG postcode: 1700 website: www.unifr.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (FRIBOURG)	coordinator	203˙149.00

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Project objective

MicroRNAs (miRNAs) are potential biomarkers for cancer diagnosis, prognosis and treatment monitoring. Specific detection and absolute quantification of miRNAs is of clinical relevance for early cancer detection and monitoring progression. The currently available techniques for miRNA detection based on DNA amplification are limited by lack of absolute quantification, low multiplexing capacity and time consumption. Here, I propose to develop a miRNA assay system based on self-assembled nanoscale DNA origami arrays (miRanDa) for the simultaneous detection of multiple miRNA targets from breast cancer cells and plasma by using DNA-PAINT, state-of-art super resolution technique. The formation of specifically configured finite 2D lattices of self-assembled DNA origami structures based on sticky-end hybridization will further improve the capacity of the detection system beyond the currently available techniques. This assay can be further developed and adapted to the rapid, specific, sensitive and multiple detection of additional nucleic acid species, such as ctDNA, mRNA or lncRNA.

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The information about "MIRANDA" are provided by the European Opendata Portal: CORDIS opendata.