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SmartSAST SIGNED

Non-covalent photoresponsive tags for photoacoustic imaging: Giving voice to living matter

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SmartSAST project word cloud

Explore the words cloud of the SmartSAST project. It provides you a very rough idea of what is the project "SmartSAST" about.

substituted    form    sound    contrast    science    progress    imaging    living    compelling    photo    multiplexing    ensures    assembly    multicomponent    guarantees    benefit    easily    biological    time    operate    smartsast    optical    good    input    pai    kinetic    complexity    operative    unlock    photoresponsive    invasively    invasiveness    penetration    designing    roots    extracting    chromophores    covalently    detector    thermokinetic    individuation    ultrasounds    benefits    bind    shifting    combination    modularity    named    microbiomes    output    nature    fundamentals    probe    engineering    invasive    modulating    activated    setups    bases    synthesis    combines    sonogens    characterization    refreshed    resolution    smart    dynamic    protein    strategies    isomerizable    supramolecular    photoacoustic    isomeric    unprecedented    dynamics    light    secure    probes    organization    rationally    indispensable    signatures    advancements    absorption    organic    appealing    visualizing    cancers    background    communication    imparts    stage    photochemical    suitable    deeply    unresolved    tags    spatial   

Project "SmartSAST" data sheet

The following table provides information about the project.

Coordinator
ECOLE NORMALE SUPERIEURE 

Organization address
address: 45, RUE D'ULM
city: PARIS CEDEX 05
postcode: 75230
website: http://www.ens.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NORMALE SUPERIEURE FR (PARIS CEDEX 05) coordinator 184˙707.00

Map

 Project objective

Visualizing the complexity of living matter non-invasively and with high-resolution represents an indispensable element for progress in science. Unresolved issues as the individuation of early-stage cancers, or the spatial organization of the roots microbiomes, can benefit from advancements in photoacoustic imaging (PAI). This appealing technology combines the benefits of light as input and ultrasounds as output, offering a compelling combination of good resolution, high penetration depth, and non-invasiveness. However, PAI is not suitable to study multicomponent living systems because current strategies operate with simple probe-detector setups. With SmartSAST (Smart Sound-activated Absorption Shifting Tags), I propose to enable modularity and multiplexing through the development of photoacoustic probes based on protein tags that non-covalently bind with photoresponsive organic chromophores named sonogens. The supramolecular nature of SmartSAST ensures great modularity as the sonogens can be easily refreshed or substituted. The change in optical properties of the probes upon assembly guarantees great contrast against the background. Finally, via rationally designing photo-isomerizable sonogens that bind the protein just in a specific isomeric form, SmartSAST imparts an unprecedented level of control in PAI. Upon photo-modulating the supramolecular dynamics of these probes and extracting their kinetic signatures, dynamic contrast and multiplexing will be achieved with high spatial resolution. SmartSAST project aims to develop a fully operative technology based on new fundamentals bases. The project includes the synthesis of sonogens, the engineering of protein tags, the thermokinetic and photochemical characterization of the probes and their application in PAI. This new approach to PAI will unlock the non-invasive study of deeply embedded complex biological targets in real-time. Dissemination and communication activities will secure the great impact of SmartSAST.

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The information about "SMARTSAST" are provided by the European Opendata Portal: CORDIS opendata.

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