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NOSCAR SIGNED

decipheriNg Oncogenic SIgnalling patterns to break CAncer drug Resistance

Total Cost €

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EC-Contrib. €

0

Partnership

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 NOSCAR project word cloud

Explore the words cloud of the NOSCAR project. It provides you a very rough idea of what is the project "NOSCAR" about.

computer    fourth    locally    dynamics    patient    combines    tumor    biosensor    cancer    perturbations    dynamic    training    ecosystem    oncogenic    signalling    genetic    organoids    components    spheroid    survive    successfully    drug    combinations    delineate    fellowship    explore    statistical    perturbed    cell    self    despite    heterogeneity    patients    pi3k    mutations    restart    signaling    quantitative    breast    resistance    progress    compromised    treat    cells    akt    clinically    disease    confer    receive    promise    vulnerabilities    benefit    erk    decisions    modern    prospects    fate    therapy    single    robustness    career    structures    patterns    multiplexed    cellular    cure    reports    thanks    rewired    limit    biology    atlas    mechanisms    network    significantly    avenues    treatment    aggressive    mutation    mentoring    insights    therapies    academic    noscar    latter    compendium    organizing    framework    drugs    ras    cultures    vision    3d   

Project "NOSCAR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 304˙724 €
 EC max contribution 304˙724 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 304˙724.00

Map

 Project objective

Despite significant progress in drug therapies for breast cancer, about one fourth of patients still do not survive the disease. Modern, targeted therapies have been proposed to cure the more advanced and aggressive cases of breast cancer. However, non-genetic and genetic mechanisms of drug resistance currently limit the promise of targeted therapy. NOSCAR aims to define the oncogenic Ras/Erk and PI3K/Akt signalling states relevant to breast cancer oncogenic mutations, and delineate the mechanisms which enable development of cancer resistance to targeted therapies. NOSCAR’s objectives are: Using a quantitative cell biology framework that combines a multiplexed biosensor system that reports on Erk/Akt dynamics at single cell level, computer vision, and statistical modelling, I will: (1) produce an atlas of single-cell Erk/Akt dynamic signalling patterns that are associated with a compendium of clinically-relevant breast cancer mutations; (2) measure the signalling states in cells perturbed with clinically-relevant drugs that target different components of the Ras/Erk and PI3K/Akt pathways to evaluate how the oncogenic signalling network is rewired by drug treatment; (3) measure signalling dynamics in 3D spheroid cultures and patient-derived organoids to explore how a self-organizing cellular ecosystem can spatially control signalling at the single cell level to locally control fate decisions, and how the latter process is compromised by an oncogenic mutation. This will provide new insights about tumor heterogeneity and signaling network structures that confer robustness against drug perturbations. We expect to identify vulnerabilities that might be efficiently targeted by drug combinations, providing new avenues to treat breast cancer. The planned research together with training and mentoring that I will receive thanks to the fellowship, will enable to successfully restart my career in research and will significantly benefit my further academic career prospects.

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The information about "NOSCAR" are provided by the European Opendata Portal: CORDIS opendata.

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