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CoMPOSE SIGNED

Cortical Microcircuits: Parvalbumin neurons Orchestrate Stress Eating

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CoMPOSE project word cloud

Explore the words cloud of the CoMPOSE project. It provides you a very rough idea of what is the project "CoMPOSE" about.

underlying    coordinated    society    chemogenetic    combination    situation    pfc    health    patterns    interneurons    behavior    inhibitory    levels    alarming    roles    enhanced    human    yield    modern    regions    viral    phenomenon    coordinate    easily    prevention    dietary    sending    cortical    structure    neural    vulnerable    mice    vivo    strategies    overeat    neurons    point    opposing    heterogenous    disorder    animal    tracing    rising    leads    physical    intake    people    recordings    continuous    cheap    output    regulation    stress    serves    prefrontal    severe    choices    circuit    local    caloric    drive    critical    psychological    shift    maladaptive    obesity    cortex    unhealthy    mechanisms    projection    arises    consequence    brain    indicates    eating    energy    shape    purpose    electrophysiological    stressors    pyramidal    replenish    stores    binge    food    neuronal    tight    understand    manner    feeding    adaptive    manipulate    techniques    accessible    circuits   

Project "CoMPOSE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 187˙572.00

Map

 Project objective

Stress leads to enhanced food intake and a shift in dietary choices towards more high-caloric and unhealthy food. While this serves an adaptive purpose to replenish energy stores after a physical challenge, in modern society where continuous psychological stressors are present and cheap unhealthy food easily accessible, this leads to an alarming situation where many people overeat. As a consequence, obesity levels are rising with severe consequences for our health. Especially people with an eating disorder, like binge-eating disorder, are vulnerable to this situation. Human and animal studies both point to a critical role of the prefrontal cortex (PFC) in coordinating stress-induced food intake. The prefrontal cortex is a highly heterogenous structure sending coordinated neuronal output to many brain regions with opposing roles in food regulation. This indicates that these circuits are under tight regulation of local interneurons. However how interneurons coordinate circuits for stress-induced feeding behavior is not known. In this project I aim to understand how Inhibitory interneurons shape output patterns of prefrontal cortical pyramidal neurons in a projection-specific manner to drive stress-induced food intake. To this aim I will use a combination of viral tracing techniques and in vivo electrophysiological recordings of identified PFC interneurons and pyramidal neurons in mice. Moreover I will use chemogenetic approaches to manipulate specific PFC pyramidal neural circuits to understand their role in stress eating responses. This will yield important insight into the circuit mechanisms underlying this maladaptive behavior. Studying how this phenomenon arises at the level of neuronal circuits will provide evidence-based targets for prevention strategies.

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The information about "COMPOSE" are provided by the European Opendata Portal: CORDIS opendata.

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