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CoMPOSE SIGNED

Cortical Microcircuits: Parvalbumin neurons Orchestrate Stress Eating

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CoMPOSE project word cloud

Explore the words cloud of the CoMPOSE project. It provides you a very rough idea of what is the project "CoMPOSE" about.

feeding    opposing    choices    situation    chemogenetic    cortical    prefrontal    critical    caloric    consequence    neural    maladaptive    local    yield    patterns    manner    coordinate    society    alarming    severe    arises    vulnerable    point    continuous    neurons    heterogenous    viral    roles    unhealthy    prevention    strategies    levels    regions    understand    cheap    output    cortex    obesity    shape    structure    techniques    stores    mice    vivo    tracing    neuronal    tight    replenish    disorder    coordinated    leads    overeat    underlying    health    pyramidal    modern    accessible    interneurons    brain    human    rising    regulation    serves    stress    dietary    energy    easily    combination    binge    phenomenon    intake    psychological    animal    manipulate    mechanisms    pfc    projection    drive    inhibitory    stressors    physical    circuit    people    behavior    shift    indicates    food    enhanced    eating    sending    recordings    purpose    electrophysiological    adaptive    circuits   

Project "CoMPOSE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 187˙572.00

Map

 Project objective

Stress leads to enhanced food intake and a shift in dietary choices towards more high-caloric and unhealthy food. While this serves an adaptive purpose to replenish energy stores after a physical challenge, in modern society where continuous psychological stressors are present and cheap unhealthy food easily accessible, this leads to an alarming situation where many people overeat. As a consequence, obesity levels are rising with severe consequences for our health. Especially people with an eating disorder, like binge-eating disorder, are vulnerable to this situation. Human and animal studies both point to a critical role of the prefrontal cortex (PFC) in coordinating stress-induced food intake. The prefrontal cortex is a highly heterogenous structure sending coordinated neuronal output to many brain regions with opposing roles in food regulation. This indicates that these circuits are under tight regulation of local interneurons. However how interneurons coordinate circuits for stress-induced feeding behavior is not known. In this project I aim to understand how Inhibitory interneurons shape output patterns of prefrontal cortical pyramidal neurons in a projection-specific manner to drive stress-induced food intake. To this aim I will use a combination of viral tracing techniques and in vivo electrophysiological recordings of identified PFC interneurons and pyramidal neurons in mice. Moreover I will use chemogenetic approaches to manipulate specific PFC pyramidal neural circuits to understand their role in stress eating responses. This will yield important insight into the circuit mechanisms underlying this maladaptive behavior. Studying how this phenomenon arises at the level of neuronal circuits will provide evidence-based targets for prevention strategies.

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The information about "COMPOSE" are provided by the European Opendata Portal: CORDIS opendata.

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