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PIGENDEF

Towards marker assisted selection against genetic defects in pigs

Coordinatore	KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Ms. Nome: Tine Cognome: Heylen Email: send email Telefono: +32 116 32 65 20 Fax: +32 16 32 65 15
Nazionalità Coordinatore	Belgium [BE]
Sito del progetto	http://www.pigendef.org
Totale costo	1˙002˙380 €
EC contributo	732˙600 €
Programma	FP7-SME Specific Programme "Capacities": Research for the benefit of SMEs
Code Call	FP7-SME-2010-1
Funding Scheme	BSG-SME
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-01-01 - 2013-06-30

Partecipanti

#	participant	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Ms. Nome: Tine Cognome: Heylen Email: send email Telefono: +32 116 32 65 20 Fax: +32 16 32 65 15	BE (LEUVEN)	coordinator	57˙220.00
2	NORSVIN FORENING Organization address address: FURNESVEGEN 223 city: HAMAR postcode: 2319 contact info Titolo: Dr. Nome: Bjarne Cognome: Holm Email: send email Telefono: 4762510100 Fax: 4762510101	NO (HAMAR)	participant	333˙090.00
3	RATTLEROW SEGHERS NV Organization address address: OEVERSTRAAT 21 city: LOKEREN postcode: 9160 contact info Titolo: Mr. Nome: Geert Cognome: Spincemaille Email: send email Telefono: +32 9 345 0191 Fax: +32 9 348 44 87	BE (LOKEREN)	participant	333˙090.00
4	NORDIC GENETICS AB Organization address address: Raby 2003 city: Horby postcode: 24292 contact info Titolo: Dr. Nome: Timo Cognome: Serenius Email: send email Telefono: 358404000000 Fax: 4641519449	SE (Horby)	participant	3˙600.00
5	SOCIETA AGRICOLA S. FOSCA DI GEMIN ARMIDO & C. S.S. SOCIETA SEMPLICE Organization address address: VIA CA MATTA FRAZIONE 12/A city: VEDELAGO postcode: 31050 contact info Titolo: Mr. Nome: Silvano Cognome: Bolzonello Email: send email Telefono: 390423000000 Fax: 390423000000	IT (VEDELAGO)	participant	3˙200.00
6	SELECCION BATALLE SA Organization address address: AVENIDA DELS SEGADORS city: RIUDARENES postcode: 17421 contact info Titolo: Mr. Nome: Jordi Cognome: Arimany Email: send email Telefono: +34 972 856 363 Fax: +34 972 856 374	ES (RIUDARENES)	participant	2˙400.00
7	NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET Organization address address: UNIVERSITETSTUNET 3 city: AS postcode: 1430 contact info Titolo: Dr. Nome: Rune Cognome: Eikanger Email: send email Telefono: 4764965229 Fax: 4764965101	NO (AS)	participant	0.00
8	UNIVERSITE DE LIEGE Organization address city: LIEGE postcode: 4000 contact info Titolo: Dr. Nome: Anne-Sophie Cognome: Lequarré Email: send email Telefono: +32 43 66 41 57 Fax: +32 43 66 41 98	BE (LIEGE)	participant	0.00

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markers causative genes economic pigs significant norway animal defects sme groups companies poor swine marker underlying producers efforts assisted welfare hernia umbilical genetic identification problem pig disorders snps congenital breeding pigendef

Obiettivo del progetto (Objective)

'The project focuses on the rapid identification of genes underlying congenital disorders in pigs for effective marker assisted selection (MAS) against genetic defects. The occurrence of congenital hereditary disorders is a significant problem for pig producers and selection compagnies and leads to poor animal welfare and severe economic loss. For most of these defects there are strong indications for a genetic component and different research groups all over Europe have made efforts to find the underlying causative genetic mechanisms. However, the mode of inheritance seems complex and no genes or mutations have been identified yet. This project aims to group the efforts of different research groups that are currently working on inherited genetic defects in pigs. Through this collaboration a faster identification of the genes and suitable gene markers for use in marker assisted selection against defects in pigs will be obtained. Thereafter, these markers can be implemented in the breeding programs of the different SME partners and can (later) be commercialised, which will improve the competitive position of the SME partners.'

Descrizione progetto (Article)

Congenital diseases are quite common in swine and they cover a wide range of undesirable conditions, including hernias, anatomical defect and ataxia.

These abnormalities lead to poor animal welfare and economic losses, posing a significant problem for pig producers and breeding companies.The aim of the EU-funded 'Towards marker assisted selection against genetic defects in pigs' (http://www.pigendef.eu (PIGENDEF)) project was to provide insight into the genetic background of congenital genetic defects in pigs.

The consortium consisted of scientific groups and companies active in pig breeding.

The research was focused on three swine defects, namely inguinal hernia, umbilical hernia and cryptorchidism, and the plan was to identify associated genes.To this end, researchers performed genome-wide association studies (GWASs) in porcine samples from Belgium and Norway for genetic markers (single nucleotide polymorphisms (SNPs)) linked with a predisposition to the aforementioned defects.

Over 120 SNPs associated with umbilical hernia were located on chromosomes 5 and 14, which were identified as significant quantitative trait locus regions.

Two genes on chromosome 14 were found to contain some significant SNPs in the Norwegian swine lines.This SNP panel was formulated into a genetic test and will be implemented for selection against the prevalence of umbilical hernia in Norway's breeding programmes.

This is expected to improve the efficiency and profitability of animal production and, therefore, the competitiveness of the small business partners.

Under the overall framework of European policies on sustainability and on animal health and welfare, PIGENDEF partners envision a causative mutation for umbilical hernia to be identified in the immediate future.