HPV-AHEAD
Role of human papillomavirus infection and other co-factors in the aetiology of head and neck cancer in India and Europe
| Coordinatore | CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
Organization address
address: Cours Albert-Thomas 150 contact info |
| Nazionalità Coordinatore | France [FR] |
| Sito del progetto | http://hpv-ahead.iarc.fr/ |
| Totale costo | 4˙192˙381 € |
| EC contributo | 2˙999˙946 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2011-single-stage |
| Funding Scheme | CP-FP |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-09-01 - 2015-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
Organization address
address: Cours Albert-Thomas 150 contact info |
FR (LYON CEDEX 08) | coordinator | 1˙217˙848.80 |
| 2 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM
Organization address
address: Im Neuenheimer Feld 280 contact info |
DE (HEIDELBERG) | participant | 424˙272.00 |
| 3 |
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Organization address
address: Via Filodrammatici 10 contact info |
IT (MILANO) | participant | 217˙800.00 |
| 4 |
INSTITUT CATALA D'ONCOLOGIA
Organization address
address: "AVDA. Gran Via KM 2,7 S/N" contact info |
ES ("HOSPITALET DEL LLOBREGAT, BARCELONA") | participant | 200˙958.00 |
| 5 |
UNIVERSITEIT ANTWERPEN
Organization address
address: PRINSSTRAAT 13 contact info |
BE (ANTWERPEN) | participant | 200˙004.00 |
| 6 |
DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE
Organization address
address: Arthur-Scheunert-Allee 114-116 contact info |
DE (NUTHETAL) | participant | 199˙285.00 |
| 7 |
UNIVERSITAETSKLINIKUM HEIDELBERG
Organization address
address: IM NEUENHEIMER FELD 672 contact info |
DE (HEIDELBERG) | participant | 181˙800.00 |
| 8 |
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Organization address
address: Administration Building, University Campus contact info |
EL (THESSALONIKI) | participant | 149˙960.00 |
| 9 |
RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY
Organization address
address: MILLENIUM PARKWAY JAGATHY contact info |
IN (THIRUVANANTHAPURAM) | participant | 110˙000.00 |
| 10 |
ROCHE MTM LABORATORIES AG
Organization address
address: IM NEUENHEIMER FELD 583 contact info |
DE (HEIDELBERG) | participant | 98˙018.20 |
| 11 |
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Organization address
address: AVENIDA GRAN VIA HOSPITALET 199-203 contact info |
ES (L'HOSPITALET DE LLOBREGAT) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Human papillomavirus (HPV) is responsible for approximately 25% of head and neck cancer (HNC) worldwide and appears to be associated with a better response to treatment and improved prognosis. Evidence suggests that HPV-induced HNC has steadily increased in the USA and some European countries in the last decades. However, whether this is a worldwide phenomenon and specific risk factors are associated with it remains to be proven. In addition, little is known on the natural history and risk factors of oral HPV infection. HPV-AHEAD network aims to address these and other unanswered questions on HNC etiology and epidemiology with a focus on the role of HPV. We will assemble and analyze a large collection of plasma/sera and HNC tissues from 42 centres in 16 European countries as well as HNC tissues from 7 Indian centres together with epidemiological and clinical data. HPV status in human specimens will be evaluated by different assays in central laboratories. Epidemiological studies will be conducted to establish the overall proportion and type distribution of HPV-positive HNC at different anatomical sites in European and Indian regions as well as the time trend of the proportion of HPV-positive HNC in recent decades. Using the follow-up information on HNC patients, we will further investigate whether HPV positivity confers a better prognosis and survival. We will also conduct a study in HPV-vaccinated and non-vaccinated women in order to determine risk factors and natural history of oral HPV infections. In addition, we will search for new surrogate markers for oral HPV infection to facilitate novel screening strategies. Finally, the HPV-AHEAD consortium aims to transfer technology to Indian centres as well as to develop several strategies for the training of European and Indian researchers in infections and cancers. This study will provide important insights for the screening, diagnosis, treatment and prophylaxis of HPV-associated HNC in Europe, India and elsewhere.'
Introduzione (Teaser)
The steadily increasing incidence of head and neck cancer (HNC) in Europe and the United States highlights the need to determine causative factors. Researchers are working on deciphering the role of human papillomavirus (HPV) infection in HNC development.