ROBOYEAST

Robustness of Yeast Strains and Bioprocesses for Industrial Production of Novel Compounds

Coordinatore	UNIVERSITAET STUTTGART    more  Organization address address: Keplerstrasse 7 city: STUTTGART postcode: 70174 contact info Titolo: Prof. Nome: Ralf Cognome: Takors Email: send email Telefono: +49 711 68564535 Fax: +49 711 68565164
Nazionalità Coordinatore	Germany [DE]
Totale costo	2˙678˙632 €
EC contributo	2˙071˙347 €
Programma	FP7-KBBE Specific Programme "Cooperation": Food, Agriculture and Biotechnology
Code Call	FP7-KBBE-2011-5
Funding Scheme	CP-TP
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-10-01   -   2014-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAET STUTTGART  Organization address address: Keplerstrasse 7 city: STUTTGART postcode: 70174 contact info Titolo: Prof. Nome: Ralf Cognome: Takors Email: send email Telefono: +49 711 68564535 Fax: +49 711 68565164	DE (STUTTGART)	coordinator	709˙270.00
2	TECHNISCHE UNIVERSITEIT DELFT  Organization address address: Stevinweg 1 city: DELFT postcode: 2628 CN contact info Nome: Rogier Cognome: Van Loghem Email: send email Telefono: +31 15 2789695 Fax: +31 15 2784301	NL (DELFT)	participant	834˙958.00
3	FLUXOME SCIENCES A/S  Organization address address: GYMNASIEVEJ 5 city: STENLOSE postcode: 3660 contact info Titolo: Ms. Nome: Sarah Cognome: Barrett Email: send email Telefono: 4547188403	DK (STENLOSE)	participant	527˙119.00

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 Obiettivo del progetto (Objective)

'Fast developments in synthetic biology now enable introduction of entire novel-to-nature pathways into industrial microorganisms, thus opening the door to a novel bio-based industry. However, successful scale-up of novel-to-market products from bench-top proof-of-principle to full-scale processes requires a profound understanding of cellular and sub-cellular mechanisms and their interaction with industrial process conditions. In particular, successful industrial production requires optimal performance of engineered strains under the dynamic, slow-growth process conditions that occur in large-scale industrial bioreactors. These differ strongly from the conditions in conventional laboratory analysis.

The RoBoYeast project aims to reduce time-to-market and to improve productivity of microbial synthetic pathways by identifying key physiological and molecular determinants of performance under industrially relevant conditions and to integrate these at an early stage in strain development programs. The project is characterized by multi-scale analysis and integration of results from industrial-scale into lab-scale studies.

RoBoYeast aims to improve productivity and cellular robustness in large-scale fermentations of the novel-to-nature production in Saccharomyces cerevisiae of arachidonic and eicosapentaenoic acid, two health-promoting poly-unsaturated fatty acids with excellent market perspectives as nutraceuticals. Biosynthetic pathways of these compounds are energy (ATP) intensive, which adds on the challenge of constructing robust strains that withstand typical production stresses without loss of productivity and product yield. To accelerate project progress, key findings of a likewise challenging resveratrol progress, already developed by the SME partner, can be used. RoBoYeast intends to identify and improve robustness mechanism not only for the benefit of this project but also as a blueprint for optimization of the production of other ATP-intensive products.'