NANOP

Nanoporous Membranes for High Throughput Rare Event Bio-analysis

Coordinatore	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	1˙497˙620 €
EC contributo	1˙497˙620 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2011-StG_20101014
Funding Scheme	ERC-SG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-01-01   -   2016-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Dr. Nome: Joshua Cognome: Edel Email: send email Telefono: +44 2075940754	UK (LONDON)	hostInstitution	1˙497˙620.00
2	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Brooke Cognome: Alasya Email: send email Telefono: +44 207 594 1181 Fax: +44 207 594 1418	UK (LONDON)	hostInstitution	1˙497˙620.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'A novel analytical platform is proposed to detect and identify DNA at low concentration in a high throughput manner at the single molecule level.

The potential impact of this research is significant and will result in single molecule detection becoming a mainstream tool within the medical diagnostics and analytical communities. 'Rare event' detection plays an important role in the early detection of illnesses and disease (e.g. cancers and bacterial infections). Using analytical technologies that exist today it is almost impossible to detect a single DNA strand within a standard blood sample (of a few mLs) within a reasonable time frame. The technology that will be developed within the current project will allow for such detection to be performed both rapidly and efficiently. If successful, the core technology described will become a mainstream analytical tool that will be of significant benefit within biomedical laboratories, hospitals, and clinics around the world.

Specifically, chemical and semiconductor processing methods will be developed to define a novel approach to high throughput DNA quantification at the single molecule level. This innovative technology will function by introducing biological samples in micro- and nanofluidic chips and using electric fields to direct DNA strands through nanometre-sized pores on a membrane. Detection and sizing of the individual DNA strands (labelled with fluorophores) is then accomplished using confocal fluorescence spectroscopy.

This new approach to high-throughput, single molecule DNA analysis harnesses the strengths of both analytical spectroscopy and silicon fabrication technology to allow the creation of hybrid devices in which molecular quantification can be realized. I expect this work to have major impact and open up new possibilities for nano-analytical tools in the chemical and biological sciences.'