PROCARDIO
Cardiovascular Risk from Exposure to Low-dose and Low-dose-rate Ionizing Radiation
| Coordinatore | HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Organization address
address: Ingolstaedter Landstrasse 1 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 5˙489˙075 € |
| EC contributo | 2˙998˙386 € |
| Programma | FP7-EURATOM-FISSION
EURATOM: Nuclear fission and radiation protection |
| Code Call | FP7-Fission-2011 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-10-01 - 2015-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Organization address
address: Ingolstaedter Landstrasse 1 contact info |
DE (MUENCHEN) | coordinator | 679˙796.00 |
| 2 |
THE UNIVERSITY OF BIRMINGHAM
Organization address
address: Edgbaston contact info |
UK (BIRMINGHAM) | participant | 330˙000.00 |
| 3 |
INSTITUT GUSTAVE ROUSSY
Organization address
address: Rue Camille Desmoulins 39 contact info |
FR (VILLEJUIF) | participant | 269˙560.00 |
| 4 |
GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH
Organization address
address: PLANCKSTRASSE 1 contact info |
DE (DARMSTADT) | participant | 240˙000.00 |
| 5 |
STUDIECENTRUM VOOR KERNENERGIE
Organization address
address: Herrmann Debrouxlaan 40 contact info |
BE (Brussel) | participant | 231˙200.00 |
| 6 |
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O
Organization address
address: Oskar-von-Miller-Ring 29 contact info |
DE (MUENCHEN) | participant | 229˙999.60 |
| 7 |
FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL
Organization address
address: Calle Doctor Aiguader 88 contact info |
ES (BARCELONA) | participant | 218˙800.00 |
| 8 |
Southern Urals Biophysics Institute
Organization address
address: Ozyorskoe shosse 19 contact info |
RU (Ozyorsk) | participant | 200˙000.00 |
| 9 |
AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE,L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE
Organization address
address: Lungotevere Grande Ammiraglio Thaon di Revel 76 contact info |
IT (ROMA) | participant | 184˙995.00 |
| 10 |
RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN
Organization address
address: Antonie Van Leeuwenhoeklaan 9 contact info |
NL (BILTHOVEN) | participant | 154˙998.00 |
| 11 |
Department of Health
Organization address
address: Quarry House, Quarry Hill contact info |
UK (Leeds) | participant | 102˙699.96 |
| 12 |
Academisch Medisch Centrum bij de Universiteit van Amsterdam
Organization address
address: MEIBERGDREEF 9 contact info |
NL (AMSTERDAM) | participant | 80˙000.00 |
| 13 |
HEALTH PROTECTION AGENCY HPA
Organization address
address: Central Office - 7th Floor, Holborn Gate - High Holborn 330 contact info |
UK (LONDON) | participant | 76˙338.04 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'Epidemiological evidence has established a link between cardiovascular disease and exposure of the heart and major vessels to doses above 500mGy. At lower doses the evidence for a detrimental effect is inconclusive. In part, this is due to the lack of appropriate epidemiological studies, coupled with lack of knowledge of the processes involved that is needed for construction of mathematical models. The ProCardio consortium will study cardiovascular outcomes in childhood cancer survivors where the radiation doses given to the heart are available. These data will be interrogated using new mathematical models developed from the data from our molecular and biological studies. These will use state-of-the-art technologies to map cardiovascular changes after photon irradiation at both low doses and low dose rates. This will be complemented by comparative studies using high LET irradiation. We will apply an integrative approach to combine transcriptional (mRNA and miRNA) and translational (proteomics) studies to understand the disease processes. High throughput proteomics (ICPL, SILAC and label-free analysis) will be used to identify new biomarkers of radiation-induced cardiovascular disease for future molecular epidemiological studies. These will be validated using the archives of cardiovascular tissue samples from the Mayak facility.'
Introduzione (Teaser)
Epidemiological evidence has established a link between cardiovascular disease (CVD) and radiation exposure of the heart and major vessels to doses above 500 milligray (mGy). A new approach for epidemiological data processing is necessary to evaluate the effects of low-dose radiation.