NANOBIO4TRANS

A new nanotechnology-based paradigm for engineering vascularised liver tissue for transplantation

Coordinatore	DANMARKS TEKNISKE UNIVERSITET    more  Organization address address: Anker Engelundsvej 1, Building 101A city: KONGENS LYNGBY postcode: 2800 contact info Titolo: Prof. Nome: Jenny Cognome: Emneus Email: send email Telefono: +45 45256867
Nazionalità Coordinatore	Denmark [DK]
Totale costo	7˙738˙695 €
EC contributo	5˙968˙093 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2012-INNOVATION-2
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-09-01   -   2015-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	DANMARKS TEKNISKE UNIVERSITET  Organization address address: Anker Engelundsvej 1, Building 101A city: KONGENS LYNGBY postcode: 2800 contact info Titolo: Prof. Nome: Jenny Cognome: Emneus Email: send email Telefono: +45 45256867	DK (KONGENS LYNGBY)	coordinator	1˙716˙653.00
2	TAKARA BIO EUROPE AB  Organization address address: ARVID WALLGRENS BACKE 20 city: GOETEBORG postcode: 413 46 contact info Titolo: Ms. Nome: Karina Cognome: Lövstedt Email: send email Telefono: +46 31 758 0963	SE (GOETEBORG)	participant	1˙315˙690.00
3	RIJKSUNIVERSITEIT GRONINGEN  Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP contact info Titolo: Dr. Nome: Dick Cognome: Veldhuis Email: send email Telefono: +31 50 363 4142	NL (GRONINGEN)	participant	1˙191˙000.00
4	LUXCEL BIOSCIENCES LTD  Organization address address: BIOTRANSFER UNIT SUITE 3-32 BIOL city: CORK contact info Titolo: Prof. Nome: Dmitri Cognome: Papkovsky Email: send email Telefono: +353 21 4901698	IE (CORK)	participant	1˙166˙500.00
5	BIOMODICS APS  Organization address address: STENGARDS ALLE 31A city: KGS LYNGBY postcode: 2800 contact info Titolo: Dr. Nome: Peter Cognome: Thomsen Email: send email Telefono: +45 33232042	DK (KGS LYNGBY)	participant	578˙250.00

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 Obiettivo del progetto (Objective)

'Organ transplantation is often the only life saving medical approach for several diseases, in spite of many associated problems (lack of organ donors, rejection, life-long heavy medication). The innovative therapeutic approach of the 21th century is focusing on bioartificial organs as an alternative solution.Tissue engineering and stem cell biology have uncovered groundbreaking opportunities for cellular re-programming, i.e., some cell types can be changed into a pluripotent stem cell (PSC) by over-expressing key transcription factors. These induced pluripotent stem cells (iPSC) share two key characteristics with embryonic stem cells (eSC): self-renewal and pluripotency (ability to differentiate to form any cell type in the human body). Crucially, they are generated from adult cells circumventing many ethical concerns associated with using human eSC. The discovery of human iPSC (hiPSC) enables the growth of an almost unlimited supply of a patient´s own cells, potentially conferring the ability to grow and regenerate tissues and organs from ‘self’, which is expected to resolve organ rejection-related issues. Similarly, recent developments in material science and nanobiotechnology resulted in engineered materials and devices (manipulated and controlled by physical and chemical means), with unique functional or analytical properties. NanoBio4Trans will merge hiPSC-, polymer hybrid scaffolds and biosensor technologies to develop new tools (beyond state-of-the-art) for use in transplantation and biomedical research. The international, trans-sectoral, and multidisciplinary consortium with complementary and leading expertise in material sciences, cell- and molecular biology, sensor technologies, and bioanalytics, aims at developing, optimising and validating a highly vascularised in vivo-like BAL as an extracorporeal bioartificial liver (EBAL), ready to be perfused with human blood plasma, and to be exploited in modern medical technology.'