RNAIGENREG

RNAi-mediated genome regulation

Coordinatore	FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	1˙599˙992 €
EC contributo	1˙599˙992 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2011-StG_20101109
Funding Scheme	ERC-SG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-01-01   -   2016-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	Novartis Forschungsstiftung  Organization address address: Maulbeerstrasse 66 city: BASEL postcode: 4058 contact info Titolo: Ms. Nome: Dorothy Cognome: Searles Email: send email Telefono: +41 61 6972982 Fax: +41 61 6973976	CH (BASEL)	beneficiary	0.00
2	FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH  Organization address address: MAULBEERSTRASSE 66 city: BASEL postcode: 4058 contact info Titolo: Mrs. Nome: Searles Cognome: Dorothy Email: send email Telefono: +41 61 6972982 Fax: +41 61 6973976	CH (BASEL)	hostInstitution	1˙599˙992.00
3	FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH  Organization address address: MAULBEERSTRASSE 66 city: BASEL postcode: 4058 contact info Titolo: Prof. Nome: Marc Cognome: Bühler Email: send email Telefono: +41 61 6960438 Fax: +41 61 697 39 76	CH (BASEL)	hostInstitution	1˙599˙992.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'RNA interference (RNAi) is a highly conserved, sequence-specific gene regulatory mechanism among eukaryotes. It is critical for a variety of important biological functions and is being pursued as a promising new tool for the treatment of a variety of human maladies. A surprising link between heterochromatin and the RNAi pathway was discovered a few years ago in fission yeast and plants, and similar mechanisms have more recently been described in various eukaryotes. However, to what extent the mechanisms we have been studying in yeast are conserved up to humans remains unknown. The goal of this proposal is to further our understanding of RNAi-mediated heterochromatin assembly by using fission yeast as a model organism, but also to investigate to role of RNAi in the nucleus of human cells. My proposal consists of three major aims. In aim 1 I propose to combine light and electron microscopy to address important and largely unanswered questions such as subcellular localization and temporal regulation of the RNAi pathway. Aim 2 builds on our recent discovery that RNAi factors physically associate with chromatin to control genome activity also outside constitutive heterochromatin. I am proposing experiments in fission yeast that aim at understanding the biological role of this new mode of genome regulation and its mechanistic dissection . However, we will also extend our analysis to human cells which will shed new light on the role of the RNAi pathway in the nucleus of higher eukaryotes. Finally, we are aiming at identifying the features a target locus in the S. pombe genome must have to become susceptible to RNAi-mediated silencing at the level of chromatin. Thus, the outcome of these experiments may substantially influence the developments of siRNA-based therapeutics.'