MOPIT

Molecular photoacoustic imaging of stem-cell driven tissue regeneration

Coordinatore	TECHNISCHE UNIVERSITAT BERLIN    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	1˙622˙736 €
EC contributo	1˙622˙736 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2011-StG_20101109
Funding Scheme	ERC-SG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-01-01   -   2016-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CHARITE - UNIVERSITAETSMEDIZIN BERLIN  Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 contact info Titolo: Ms. Nome: Martina Cognome: Eickmann Email: send email Telefono: +49 30 450576376 Fax: +49 30 450576954	DE (BERLIN)	beneficiary	694˙427.20
2	TECHNISCHE UNIVERSITAT BERLIN  Organization address address: STRASSE DES 17 JUNI 135 city: BERLIN postcode: 10623 contact info Titolo: Dr. Nome: Gottfried Jan Cognome: Laufer Email: send email Telefono: +49 30 314 23776 Fax: +49 30 314 21079	DE (BERLIN)	hostInstitution	928˙308.80
3	TECHNISCHE UNIVERSITAT BERLIN  Organization address address: STRASSE DES 17 JUNI 135 city: BERLIN postcode: 10623 contact info Titolo: Mrs. Nome: Silke Cognome: Hönert Email: send email Telefono: +49 30 314 79973 Fax: +49 30 314 21689	DE (BERLIN)	hostInstitution	928˙308.80

Mappa

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 Obiettivo del progetto (Objective)

'I propose to develop a new generation of molecular photoacoustic imaging technologies and methods capable of detecting single deep tissue cells in preclinical studies of tissue regeneration. In order to achieve this goal, an interdisciplinary research programme involving physicists, engineers and life scientists is required to address the following objectives: 1) the development of novel photoacoustic imaging technology that provides high sensitivity and acquisition speed, 2) the development of the theoretical framework and experimental methods for quantitative imaging, 3) the development of novel genetically expressed reporters, and 4) the preclinical application in small animal models of tissue regeneration. This will result in a preclinical imaging modality has the potential to combine single cell sensitivity and microscale spatial resolution in deep (centimetre range) tissue regions with molecular, physiological, and anatomical imaging capabilities. The instrumentation and methodologies developed in this project will be applied to noninvasive, longitudinal, and quantitative studies of stem cell driven tissue regeneration, such as angiogenesis in bone fractures and muscle trauma. It will allow the detection and tracking of single stem cells and the probing of stem cell function. This will provide unprecedented opportunities for correlating cellular localization, migration, and function and with anatomical changes - knowledge that can be exploited to develop novel drugs and cell-based clinical therapies. Crucially, the technologies and methodologies developed in this project will be directly applicable to a wide range of other fields of the life sciences, such as cancer research and neurology.'