NKT CELLS IN MUCOSA

"NKT cells, CD1 expression and lipid presentation in intestinal immunity"

Coordinatore	KING'S COLLEGE LONDON    more  Organization address address: Strand city: LONDON postcode: WC2R 2LS contact info Titolo: Mr. Nome: Paul Cognome: Labbett Email: send email Telefono: 442078000000 Fax: +4420 7848 3193
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	221˙606 €
EC contributo	221˙606 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IEF
Funding Scheme	MC-IEF
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-03-01   -   2016-02-29

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KING'S COLLEGE LONDON  Organization address address: Strand city: LONDON postcode: WC2R 2LS contact info Titolo: Mr. Nome: Paul Cognome: Labbett Email: send email Telefono: 442078000000 Fax: +4420 7848 3193	UK (LONDON)	coordinator	221˙606.40

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 Obiettivo del progetto (Objective)

'The mammalian intestine is colonized by trillions of microorganisms that are critical for the establishment of tissue homeostasis. Consequently, the immune system has developed strategies to maintain a mutualistic relation with the microbiota while stopping microbial spread. However, inappropriate function of the immune cells and/or alteration of the commensal composition can lead to inflammatory and autoimmune diseases, like inflammatory bowel disease. Among the components of the intestinal immune system, NKT cells represent a predominant population with striking immune-modulatory properties. NKT cells specifically recognize and are activated by lipid antigens presented by the MHC-I-like molecule CD1. Upon antigen encounter NKT cells can induce the downstream activation of both innate (NK cells) and adaptive (B cells) immune cells. In line with the abundance and diversity of microbial-derived lipids present in the gut, numerous studies have proposed a role for NKT cells and CD1-lipid presentation in the modulation of mucosal immunity both in homeostasis and disease. However, the features of intestinal NKT cells and the mechanisms by which they exert their immunomodulatory functions remain poorly explored. This proposal aims to unravel the cellular and molecular mechanisms that mediate the role of NKT cells in the regulation of mucosal immunity. We will use a combination of flow-cytometry, immunofluorescence and microscopy to build a comprehensive picture of NKT cell distribution and phenotype within gastro-intestinal compartments. With this established we will analyse the role of NKT cells in intestinal homeostasis by deciphering their contribution to the generation and quality of intestinal B cell responses. These studies will provide a better understanding of the factors that modulate intestinal immunity, with the potential to improve therapies for patients suffering from intestinal inflammatory diseases and possibly a broader range of disorders.'