NANOTRANSKINETICS

"Modelling basis and kinetics of nanoparticle interaction with membranes, uptake into cells, and sub-cellular and inter-compartmental transport"

Coordinatore	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN    more  Organization address address: BELFIELD city: DUBLIN postcode: 4 contact info Titolo: Mr. Nome: Donal Cognome: Doolan Email: send email Telefono: 35317161656 Fax: 35317161216
Nazionalità Coordinatore	Ireland [IE]
Sito del progetto	http://www.nanotranskinetics.eu
Totale costo	1˙305˙596 €
EC contributo	993˙013 €
Programma	FP7-NMP Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
Code Call	FP7-NMP-2010-EU-USA
Funding Scheme	CP-FP
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-11-01   -   2014-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN  Organization address address: BELFIELD city: DUBLIN postcode: 4 contact info Titolo: Mr. Nome: Donal Cognome: Doolan Email: send email Telefono: 35317161656 Fax: 35317161216	IE (DUBLIN)	coordinator	392˙856.00
2	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN  Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 contact info Titolo: Prof. Nome: Joachim Cognome: Raedler Email: send email Telefono: +4989 2180 2437 Fax: +4989 2180 3182	DE (MUENCHEN)	participant	314˙400.00
3	UNIVERSITAT DE BARCELONA  Organization address address: GRAN VIA DE LES CORTS CATALANES 585 city: BARCELONA postcode: 8007 contact info Titolo: Mr. Nome: Xavier Cognome: Gutierrez Email: send email Telefono: +34 93 403 53 85 Fax: +34 93 448 94 34	ES (BARCELONA)	participant	285˙757.00

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 Obiettivo del progetto (Objective)

'The prediction of biological (and in particular toxicological) impacts has, as its basic pre-requisite, the correct prediction of the sites of action and localization of the nanoparticle in living organisms. We have identified the need for a paradigm shift in modelling these properties for nanoscale objects. The interactions between bare particles and organisms (cells, biological barriers) is radically different in the presence of proteins and lipids derived from the biological environment (the ‘protein corona’). The bare particle characteristic is therefore insufficient to describe the system. Similarly, nanoparticles are trafficked and translocated between sites by active biological processes where traditional ‘equilibrium’ principles for small molecules no longer apply. NanoTransKinetics is firmly based on advanced high quality experimental data on the distribution of nanoparticles in cells, across barriers, and (more limited) in vivo. We frame phenomenological models in a modular manner by abstracting the essential relevant principles of particle-protein (and matrix) interactions, cellular and barrier transport mechanisms of nanoparticles, fitting them to experimental data. More detailed models allow for explicit checking of mechanisms and movements of individual particles into cells and across barriers. Enormous amounts of experimental data are now available to validate the models. A predictive capacity requires only simple input data on particle, corona and similar characteristics. The basis of these claims has been checked in preliminary studies, and a limited number of interactions, particles fluxes (and control parameters) between prescribed sites are sufficient to specify the system at each level of description. Resources (reaching far beyond the program itself) have been mobilised in experimental work in the Partners laboratories, and EU and US collaborations. The output will be predictive tools for use in nanosafety research and regulation and beyond.'

Introduzione (Teaser)

Nanomaterials are revolutionising fields as diverse as energy and medicine. EU-funded scientists are developing mathematical models to predict their hazards, thereby guiding design and regulation to ensure human and environmental safety.