BACATTACK

A stealth attack tool for preventing clinical drug resistance through a unique self-regenerating surface

Coordinatore	TEKNOLOGISK INSTITUT    more  Organization address address: GREGERSENSVEJ 1 city: TAASTRUP postcode: 2630 contact info Titolo: Dr. Nome: Anne-Lise Høg Cognome: Lejre Email: send email Telefono: +45 7220 3116
Nazionalità Coordinatore	Denmark [DK]
Totale costo	3˙890˙118 €
EC contributo	2˙990˙698 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-two-stage
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-01-01   -   2015-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TEKNOLOGISK INSTITUT  Organization address address: GREGERSENSVEJ 1 city: TAASTRUP postcode: 2630 contact info Titolo: Dr. Nome: Anne-Lise Høg Cognome: Lejre Email: send email Telefono: +45 7220 3116	DK (TAASTRUP)	coordinator	823˙780.00
2	BACTIGUARD AB  Organization address address: BIBLIOTEKSGATAN 25 city: STOCKHOLM postcode: 10242 contact info Titolo: Dr. Nome: Mattias Cognome: Ohrlander Email: send email Telefono: +46 84 40 58 80 Fax: +46 84 40 58 90	SE (STOCKHOLM)	participant	539˙200.00
3	BIOMODICS APS  Organization address address: STENGARDS ALLE 31A city: KGS LYNGBY postcode: 2800 contact info Titolo: Dr. Nome: Peter Cognome: Thomsen Email: send email Telefono: +45 61 66 66 19 Fax: +45 33 23 20 48	DK (KGS LYNGBY)	participant	475˙740.00
4	LABORATOIRE D'EVALUTION DES MATERIELS IMPLANTABLES SA  Organization address city: MARTILLAC postcode: 33650 contact info Titolo: Mr. Nome: Pierre Cognome: Gonfrier Email: send email Telefono: +33 55 66 49 000 Fax: +33 55 66 49 002	FR (MARTILLAC)	participant	367˙564.00
5	ST GEORGE'S HOSPITAL MEDICAL SCHOOL  Organization address address: Cranmer Terrace city: LONDON postcode: SW17 0RE contact info Titolo: Prof. Nome: Anthony Cognome: Coates Email: send email Telefono: +44 20 87 25 57 25	UK (LONDON)	participant	338˙881.00
6	WEIZMANN INSTITUTE OF SCIENCE  Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 contact info Titolo: Ms. Nome: Talia Cognome: Tzahor Email: send email Telefono: +972 8 934 4026 Fax: +972 8 934 4165	IL (REHOVOT)	participant	316˙550.00
7	NOVOZYMES A/S  Organization address address: Krogshoejvej 36 city: BAGSVAERD postcode: 2880 contact info Titolo: Ms. Nome: Nina Cognome: Eckert Busgaard Email: send email Telefono: +45 4446 0794 Fax: +45 4446 9999	DK (BAGSVAERD)	participant	128˙983.00

Mappa

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 Obiettivo del progetto (Objective)

'Outbreaks of clinical infections affect many thousands of patients in Europe yearly. The present effective treatment for infections is large doses of systemically applied drugs. There is a high risk of recurring infections and biofilm formation for patients dependent on long term in-dwelling catheters and the extended dependency on antibiotics result in clinical drug resistance. We present a new tool for minimizing drug resistance by upgrading existing and future medical devices through a unique self-regenerating surface that prevents biofilm formation by a two-fold stealth attack mechanism. This will be achieved by an interpenetrating polymer network (IPN) that allows for long term release of a range of antimicrobial strategies, such as antimicrobial peptides (AMPs) . The IPNs contain hydrogels where the AMP is stored until the release starts at the insertion of the device with an expected long-term effect. The first line of defence will be a fixed galvanic noble metal alloy coating that will prevent bacteria from colonizing the surface. Local and site-specific treatment with long term effect instead of systemic treatment implies improved patient management and citizen well-fare.'