BIO-COMET

"Bioreactor-based, clinically oriented manufacturing of engineered tissues"

Coordinatore	UNIVERSITAETSSPITAL BASEL    more  Organization address address: HEBELSTRASSE 32 city: BASEL postcode: 4031 contact info Titolo: Prof. Nome: Ivan Cognome: Martin Email: send email Telefono: +41 61 265 2384 Fax: +41 61 265 3990
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	8˙326˙237 €
EC contributo	5˙994˙367 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-two-stage
Funding Scheme	CP-FP
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-12-01   -   2015-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAETSSPITAL BASEL  Organization address address: HEBELSTRASSE 32 city: BASEL postcode: 4031 contact info Titolo: Prof. Nome: Ivan Cognome: Martin Email: send email Telefono: +41 61 265 2384 Fax: +41 61 265 3990	CH (BASEL)	coordinator	1˙269˙000.00
2	CELLEC BIOTEK AG  Organization address address: VOGESENSTRASSE 135 city: BASEL postcode: 4056 contact info Titolo: Dr. Nome: Montefiori Cognome: Michele Email: send email Telefono: 41762461980	CH (BASEL)	participant	885˙000.00
3	OCTANE BIOTECH INC  Organization address address: CATARAQUI WOODS DRIVE 640 city: KINGSTON postcode: K7P 2Y5 contact info Titolo: Dr. Nome: Timothy Cognome: Smith Email: send email Telefono: +1 613 484 4112	CA (KINGSTON)	participant	641˙268.00
4	ISTITUTO ORTOPEDICO RIZZOLI  Organization address address: VIA DI BARBIANO 1/10 city: BOLOGNA postcode: 40136 contact info Titolo: Dr. Nome: Andrea Cognome: Rizzi Email: send email Telefono: +39 0516366923 Fax: +39 0516447344	IT (BOLOGNA)	participant	620˙500.00
5	SVEUCILISTE U ZAGREBU  Organization address address: Trg Marsala Tita 14 city: ZAGREB postcode: 10000 contact info Titolo: Dr. Nome: Hrvoje Cognome: Matakovic Email: send email Telefono: +385 1 4698 136 Fax: +385 1 4698 136	HR (ZAGREB)	participant	614˙729.60
6	PRESENS PRECISION SENSING GMBH  Organization address address: Josef Engert Strasse 9 city: Regensburg postcode: 93053 contact info Titolo: Dr. Nome: Christian Cognome: Krause Email: send email Telefono: +49 941 94272112	DE (Regensburg)	participant	568˙200.00
7	UNIVERSITY OF BRISTOL  Organization address address: TYNDALL AVENUE SENATE HOUSE city: BRISTOL postcode: BS8 1TH contact info Titolo: Ms. Nome: Maria Cognome: Davies Email: send email Telefono: +44 117 3315176	UK (BRISTOL)	participant	559˙892.60
8	HOLOSTEM TERAPIE AVANZATE SRL  Organization address address: VIA GLAUCO GOTTARDI 100 city: MODENA postcode: 41125 contact info Titolo: Prof. Nome: Graziella Cognome: Pellegrini Email: send email Telefono: +39 059 2058064	IT (MODENA)	participant	429˙500.40
9	FIN-CERAMICA FAENZA SPA  Organization address address: Via Granarolo 177/3 city: Faenza postcode: 48018 contact info Titolo: Dr. Nome: Elisa Cognome: Figallo Email: send email Telefono: +39 0546607332	IT (Faenza)	participant	406˙276.50

Mappa

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 Obiettivo del progetto (Objective)

'Despite significant achievements in the field of regenerative medicine and the enormous potential for engineered tissue products, significant hurdles have prevented cellular therapies from gaining wide-spread clinical adoption. Manufacturing related issues have been proposed as key challenges to be addressed for the translation of regenerative therapies to the clinic and the successful commercialization of engineered products. Similar to other biotechnology sectors (e.g., vaccines or recombinant protein production), bioreactor systems could play a central role in establishing engineered tissues in the clinic. In fact, by automating and streamlining manufacturing processes, they would allow to improve product reproducibility, safety, standardization and possibly reach cost-effectiveness. This project aims at the development, pre-clinical and clinical testing of a sensor-based bioreactor system for the production of functional, autologous engineered grafts with reproducible properties. The bioreactor-based manufacturing paradigm will be addressed in the specific context of cartilage repair. Innovative features of the proposed tissue engineering strategy will include: (i) an automated and controlled production system, (ii) bioreactor conforming to regulatory guidelines, (iii) simplified, streamlined, and scalable tissue engineering process, (iv) on-line monitoring of culture/quality parameters, and (v) data management systems for traceability. To achieve these goals, BIO-COMET brings together internationally renowned leaders in the field of regenerative medicine, from academic, clinical and industrial research institutions. Successful implementation of the project will be instrumental to extend use of bioreactor-based platforms beyond cartilage tissue engineering, with the ultimate goal to facilitate broad utilization and commercialization of cell-based grafts as therapeutic solutions.'