EUROSKINGRAFT

A novel generation of skin substitutes to clinically treat a broad spectrum of severe skin defects

Coordinatore	UNIVERSITAET ZUERICH    more  Organization address address: Raemistrasse 71 city: ZURICH postcode: 8006 contact info Titolo: Dr. Nome: Ernst Cognome: Reichmann Email: send email Telefono: +41 44 63 489 11 Fax: +41 44 634 89 18
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	7˙845˙532 €
EC contributo	5˙996˙018 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-two-stage
Funding Scheme	CP-FP
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-10-01   -   2016-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAET ZUERICH  Organization address address: Raemistrasse 71 city: ZURICH postcode: 8006 contact info Titolo: Dr. Nome: Ernst Cognome: Reichmann Email: send email Telefono: +41 44 63 489 11 Fax: +41 44 634 89 18	CH (ZURICH)	coordinator	2˙904˙096.00
2	STICHTING VU-VUMC  Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV contact info Nome: Margreet Cognome: Verweij-Deddens Email: send email Telefono: +31 20 444 5463 Fax: +31 20 444 0151	NL (AMSTERDAM)	participant	874˙852.00
3	VEREIN FUER BERUFSGENOSSENSCHAFTLICHE HEILBEHANDLUNG BERLIN EV  Organization address address: WARENER STRASSE 7 city: BERLIN postcode: 12683 contact info Titolo: Dr. Nome: Dirk Cognome: Stengel Email: send email Telefono: +49 30 56814090 Fax: +49 30 56814093	DE (BERLIN)	participant	726˙060.00
4	THE MEDICAL DEVICE CO LTD  Organization address address: KAY PARK CRESCENT 42 city: KILMARNOCK postcode: KA3 7BA contact info Titolo: Mr. Nome: Jeremy Francis Cognome: Donnan Email: send email Telefono: +44 1314494636 Fax: +44 1314494636	UK (KILMARNOCK)	participant	402˙930.00
5	STICHTING KATHOLIEKE UNIVERSITEIT  Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ contact info Titolo: Mr. Nome: Wim Cognome: Van Oijen Email: send email Telefono: +31 24 3618937 Fax: +31 24 3540529	NL (NIJMEGEN)	participant	395˙580.00
6	GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O  Organization address address: Oskar-von-Miller-Ring 29 city: MUENCHEN postcode: 80333 contact info Titolo: Ms. Nome: Birgit Cognome: Fuchs Email: send email Telefono: +49 89 288 104 14 Fax: +49 89 288 104 20	DE (MUENCHEN)	participant	389˙980.00
7	MATRICEL GMBH  Organization address address: KAISERSTRASSE 100 city: HERZOGENRATH postcode: 52134 contact info Titolo: Dr. Nome: Ingo Cognome: Heschel Email: send email Telefono: +49 2407 56 44 0 Fax: +49 2407 56 44 10	DE (HERZOGENRATH)	participant	302˙520.00
8	VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG  Organization address address: De Boelelaan 1105 city: AMSTERDAM postcode: 1081 HV contact info Nome: Margreet Cognome: Verweij-Deddens Email: send email Telefono: +3120 444 5463 Fax: +31 20 444 0151	NL (AMSTERDAM)	participant	0.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Large full-thickness skin defects resulting from burns, soft tissue trauma, congenital giant nevi, tumour resection, and disease leading to skin necrosis, represent a significant and common clinical problem worldwide. This problem is far from being solved. The main challenge encountered is that most autologous skin grafting techniques are based on transplanting split-thickness skin (the today’s gold standard). Split-thickness skin contains all of the epidermis, but only remnants of the dermis. This lack of dermal tissue, frequently leads to significant scarring. Consequently, a true dermal substitute is required, which instantly exerts the cell-instructive properties of a neo-dermis. The partners of EuroSkinGraft can now offer 2 dermal substitutes, Novomaix and denovoDerm, plus the dermo-epidermal skin substitute denovoSkin. The development of all 3 substitutes was significantly supported by the FP6-program (EuroSTEC). The envisaged clinical studies are aiming strictly at a one-step surgical procedure (instead of the common two-step procedure, using Integra Artificial Skin).This is to be reached with the following protocol: Clinical application of Novomaix 1. Experimental arm 1: split-thickness skin on Novomaix applied on full-thickness wounds 2. Reference arm 1: split-thickness skin applied directly on the wound bed Clinical application of denovoDerm 1. Experimental arm 1: split-thickness skin on denovoDerm applied on full-thickness wounds 2. Reference arm 1: split-thickness skin applied directly on the wound bed Clinical application of denovoSkin 1. Experimental arm 1: denovoSkin applied on full-thickness wounds 2. Reference arm 1: split-thickness skin applied directly on the wound bed The strength of this project lies in: the high degree to which real regenerative medicine is translated into the clinic, the innovative and highly functional character of the 3 products to be tested, the central contribution of the 3 SMEs, and the excellence of the 3 clinics.'

Introduzione (Teaser)

A European research initiative is continuing development of the skin substitutes Novomaix, denovoDerm and denovoSkin. Clinical studies are testing a one-step surgical procedure.