IDEA
Dissecting the Immunological Interplay between Poverty Related Diseases and Helminth Infections: An African-European Research Initiative
| Coordinatore | HOSPICES CANTONAUX CHUV
Organization address
address: Rue du Bugnon 21 contact info |
| Nazionalità Coordinatore | Switzerland [CH] |
| Totale costo | 13˙728˙795 € |
| EC contributo | 10˙300˙000 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2009-single-stage |
| Funding Scheme | CP-IP-SICA |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-03-01 - 2015-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
HOSPICES CANTONAUX CHUV
Organization address
address: Rue du Bugnon 21 contact info |
CH (LAUSANNE) | coordinator | 1˙623˙442.00 |
| 2 |
MEDICAL RESEARCH COUNCIL
Organization address
address: NORTH STAR AVENUE POLARIS HOUSE contact info |
UK (SWINDON) | participant | 1˙449˙987.00 |
| 3 |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address
address: Albinusdreef 2 contact info |
NL (LEIDEN) | participant | 1˙042˙910.00 |
| 4 |
SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT
Organization address
address: SOCINSTRASSE 57 contact info |
CH (Basel) | participant | 840˙453.75 |
| 5 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address
address: University Offices, Wellington Square contact info |
UK (OXFORD) | participant | 804˙100.00 |
| 6 |
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
Organization address
address: KEPPEL STREET contact info |
UK (LONDON) | participant | 774˙369.75 |
| 7 |
VACCINE AND GENE THERAPY INSTITUTE OF FLORIDA CORP.
Organization address
address: SW VILLAGE PARKWAY - 3RD FLOOR 11350 contact info |
US (PORT ST LUCIE FLORIDA) | participant | 497˙940.00 |
| 8 |
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Organization address
address: GESCHWISTER-SCHOLL-PLATZ contact info |
DE (TUEBINGEN) | participant | 490˙000.00 |
| 9 | Nome Ente NON disponibile | GA | participant | 392˙036.70 |
| 10 |
ISTITUTO NAZIONALE MALATTIE INFETTIVE L.SPALLANZANI - IRCCS
Organization address
address: "Via Portuense, 292" contact info |
IT (ROMA) | participant | 333˙972.94 |
| 11 |
"College of Medicine, University of Ibadan"
Organization address
address: QUEEN ELISABETH II ROAD U.C.H. contact info |
NG (Ibadan) | participant | 300˙780.00 |
| 12 |
Academisch Medisch Centrum bij de Universiteit van Amsterdam
Organization address
address: MEIBERGDREEF 9 contact info |
NL (AMSTERDAM) | participant | 294˙800.00 |
| 13 |
EUROPEAN VACCINE INITIATIVE - EEIG
Organization address
address: IM NEUERHEIMER FELD 307 contact info |
DE (Heidelberg) | participant | 250˙000.00 |
| 14 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | participant | 247˙199.70 |
| 15 |
Fondation international de l'Hopital de Dr. Albert Schweitzer de LAMBARENE
Organization address
address: Hopital Albert Schweitzer na contact info |
GA (Lambarene) | participant | 218˙588.19 |
| 16 |
KENYA MEDICAL RESEARCH INSTITUTE
Organization address
address: Off Mbagathi Way contact info |
KE (Nairobi) | participant | 213˙700.00 |
| 17 |
IFAKARA HEALTH INSTITUTE TRUST
Organization address
address: POBOX contact info |
TZ (DAR ES SALAAM) | participant | 205˙400.00 |
| 18 |
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address
address: BATIMENT CE 3316 STATION 1 contact info |
CH (LAUSANNE) | participant | 119˙480.00 |
| 19 |
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Organization address
address: GESCHWISTER SCHOLL PLATZ 1 contact info |
DE (MUENCHEN) | participant | 106˙440.00 |
| 20 |
NATIONAL INSTITUTE FOR MEDICAL RESEARCH
Organization address
address: Ocean Road - Luthuli Street 2488 contact info |
TZ (DAR ES SALAAM) | participant | 63˙400.00 |
| 21 |
EuroVacc Foundation
Organization address
city: Lausanne contact info |
CH (Lausanne) | participant | 27˙400.00 |
| 22 |
Nome Ente NON disponibile
Organization address
address: Rue de Tolbiac 101 contact info |
FR (Paris) | participant | 3˙600.00 |
| 23 |
MALARIA CONSORTIUM LBG
Organization address
address: LEONARD STREET 56-64 contact info |
UK (LONDON) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Worm infections are receiving increased attention due to: the wide geographic overlap in occurrence between worms and HIV, TB and malaria; the large proportion of individuals (minimal estimates around 25%) co-infected with worms and HIV/TB/ malaria; the potential risk of increasing disease burden; the very limited understanding of the impact by worm infections on HIV-, TB- and malaria-specific immune responses and on their clinical outcome; the lack of established intervention guidelines for treatment of worm infections; and the scarce information on the impact by worm infections on vaccination and vaccine-induced immune responses. In order to address these complex and challenging scientific issues, IDEA project will focus its efforts on four primary objectives: a) the worm-induced modulation of the functional and molecular profile of HIV-, TB- and malaria-specific immune responses, b) the impact by worm co-infections on measures of disease activity of PRDs, c) the immunologic markers of worm-, HIV-, TB- and malaria-specific immune responses associated with better control of pathogen replication and disease, and d) the modulation by worm co-infections of vaccine-induced immune responses. To achieve these objectives, IDEA project has developed a global and innovative strategy which includes: a) the alliance between African and European leading scientists in the field of worms, HIV, TB and malaria, b) the multidisciplinary expertise involving immunologists, parasitologists, epidemiologists, clinicians, and experts in vaccines, c) cutting edge immunology and the most innovative technologies to profile immune response, d) the access to large cohort studies bringing a number of centres working on worms and PRDs in Africa together, and e) the access to experimental HIV, TB and malaria vaccine candidates under clinical development in Africa.'
Introduzione (Teaser)
Nearly one in four patients with tuberculosis (TB), malaria or HIV has parasitic worm (helminth) infections. African and European scientists joined forces to elucidate how worm infections affect the immune responses.
Descrizione progetto (Article)
Moreover, there is a wide geographic overlap in occurrence between worms and HIV, TB and malaria. The EU-supported project http://www.idearesearch.eu/ (IDEA) has been studying these connections for four years.
Partners from six European and five African countries are involved in the project. The objectives of IDEA are to understand how the presence of worm infections affect immune responses specific to HIV, TB and malaria. The effects of parasitic worms on the clinical progression of these diseases are also under study.
The IDEA Central Database was established which unifies demographic, clinical and parasitological data and allows for centralised analysis. Meta-analysis of data obtained from HIV-TB- and malaria patients' cohorts from different sites is constantly underway.
Innate, or immediate immune response elicited by worm infections has been characterised. The scientists have determined whether the worm-induced innate immune response modulates the innate and adaptive immune response to HIV, TB and malaria antigens. Preliminary results were obtained regarding immunological interplay between helminth infections and HIV- and TB-specific T cell responses.
The effects of worm infections and anti-worm treatment on incidence, clinical presentation and immune responses against worms, as well as HIV, TB and malaria have been analysed. To determine the effect of worm-infections on vaccine-induced immune responses, the researchers have started vaccine trials for HIV, TB and malaria.
The IDEA research programme has made a substantial contribution to sustained and integrated research in sub-Saharan Africa. In addition, the project will ultimately contribute to the development of new successful therapies and vaccines.
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