EPIHEALTH

"Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing."

Coordinatore	BIOTALENTUM TUDASFEJLESZTO KFT    more  Organization address address: AULICH LAJOS UTCA 26 city: GOEDOELLO postcode: 2100 contact info Titolo: Prof. Nome: Andras Cognome: Dinnyes Email: send email Telefono: +36 20 583 6250 Fax: +36 28 526 243
Nazionalità Coordinatore	Hungary [HU]
Sito del progetto	http://epihealth.biotalentum.eu/
Totale costo	3˙823˙281 €
EC contributo	2˙942˙356 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-two-stage
Funding Scheme	CP-FP
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-11-01   -   2015-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	BIOTALENTUM TUDASFEJLESZTO KFT  Organization address address: AULICH LAJOS UTCA 26 city: GOEDOELLO postcode: 2100 contact info Titolo: Prof. Nome: Andras Cognome: Dinnyes Email: send email Telefono: +36 20 583 6250 Fax: +36 28 526 243	HU (GOEDOELLO)	coordinator	661˙615.60
2	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223761648 Fax: +44 1223 332988	UK (CAMBRIDGE)	participant	516˙006.00
3	MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG  Organization address address: UNIVERSITAETSPLATZ 10 city: HALLE (Saale) postcode: 6099 contact info Titolo: Ms. Nome: Peggy Cognome: Patzner Email: send email Telefono: +49 345 5574453 Fax: +49 345 5574452	DE (HALLE (Saale))	participant	371˙841.60
4	AVANTEA srl  Organization address address: via Cabrini 12 city: Cremona postcode: 26100 contact info Titolo: Prof. Nome: Cesare Cognome: Galli Email: send email Telefono: +39 0372 437242 Fax: +39 0372 436133	IT (Cremona)	participant	364˙640.00
5	UNIVERSITY OF SOUTHAMPTON  Organization address address: Highfield city: SOUTHAMPTON postcode: SO17 1BJ contact info Titolo: Ms. Nome: Yan Cognome: Qiao Email: send email Telefono: +44 23 80593907 Fax: +44 2380592195	UK (SOUTHAMPTON)	participant	350˙964.00
6	CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL  Organization address address: OLSHAUSENSTRASSE 40 city: KIEL postcode: 24118 contact info Titolo: Ms. Nome: Susanne Cognome: Neufeldt Email: send email Telefono: +49 431 880 7246 Fax: +49 431 880 1560	DE (KIEL)	participant	346˙136.80
7	THE UNIVERSITY OF MANCHESTER  Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL contact info Titolo: Dr. Nome: Katherine Cognome: Boylan Email: send email Telefono: +44 161 275 8796 Fax: +44 161 2752445	UK (MANCHESTER)	participant	331˙152.00

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 Obiettivo del progetto (Objective)

'Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life. Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity for newly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient delivery to the needs of the developing fetus. EpiHealth will focus on these early events in several relevant models(diabetes, obesity and assisted reproductive technologies (ART)),using human samples, stem cell lines, animal models and data mining/bioinformatics tools to decipher some of the most important pathways and to offer options for early intervention to avoid adverse health effects. Main goal of the project is to improve health of the human population by understanding the mechanisms and pathways in early development, with special emphasis on epigenetic changes and developmentally relevant metabolic signalling, which create biological variation and have a long term effect on the health of individuals across the lifespan. Specific goals include: i)Identification of the main genetic pathways affecting the health of the developing embryos in a diabetic or obese maternal environment; ii) Identification of the main genetic and metabolic pathways affected and epigenomic and imprinting perturbations from mouse and human ART resulting in altered health of the progeny; iii)Discovery of the key genes and pathways affecting epigenetic and imprinting sensitivity in early stages of development in order to create intervention tools against epigenetic mis-programming; iv)Linking for the first time by bioinformatics tools the longevity related pathways and those susceptible to early epigenetic perturbations in order to explain how early events influence the health and lifespan of individuals; v)Studying the possibilities of early intervention by controlling the maternal environment.'