IONE-FP7
Implantable Organic Nano-Electronics
| Coordinatore | UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Organization address
address: VIA UNIVERSITA 4 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Totale costo | 5˙090˙468 € |
| EC contributo | 3˙834˙336 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2011-SMALL-5 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-03-01 - 2015-02-28 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Organization address
address: VIA UNIVERSITA 4 contact info |
IT (MODENA) | coordinator | 180˙885.74 |
| 2 |
CONSIGLIO NAZIONALE DELLE RICERCHE
Organization address
address: Piazzale Aldo Moro 7 contact info |
IT (ROMA) | participant | 586˙685.45 |
| 3 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | participant | 469˙894.80 |
| 4 |
SCRIBA NANOTECNOLOGIE SRL
Organization address
address: VIA DI CORTICELLA 183/8 contact info |
IT (BOLOGNA) | participant | 445˙937.00 |
| 5 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | participant | 382˙904.00 |
| 6 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 372˙996.00 |
| 7 |
LINKOPINGS UNIVERSITET
Organization address
address: CAMPUS VALLA contact info |
SE (LINKOPING) | participant | 372˙595.20 |
| 8 |
ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA
Organization address
address: Via Zamboni 33 contact info |
IT (BOLOGNA) | participant | 363˙180.00 |
| 9 |
UNIVERSIDADE DO ALGARVE
Organization address
address: CAMPUS DE PENHA contact info |
PT (FARO) | participant | 210˙712.00 |
| 10 |
CONTIPRO BIOTECH SRO
Organization address
address: DOLNI DOBROUC 401 contact info |
CZ (DOLNI DOBROUC) | participant | 180˙760.00 |
| 11 |
AMIRES SARL
Organization address
address: RUE DE LA SERRE 4 contact info |
CH (NEUCHATEL) | participant | 130˙300.00 |
| 12 |
STMICROELECTRONICS SRL
Organization address
address: VIA C.OLIVETTI 2 contact info |
IT (AGRATE BRIANZA) | participant | 116˙695.00 |
| 13 |
POLYGANICS INNOVATIONS BV
Organization address
address: ROZENBURGLAAN 15 A contact info |
NL (GRONINGEN) | participant | 20˙790.81 |
Mappa
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Obiettivo del progetto (Objective)
'The vision of iONE-FP7 is to exploit for the first time flexible organic electronics for the development and testing of Active Multifunctional Implantable Devices (AMIDs) to treat Spinal Cord Injury (SCI). The devices will (a) have long-term stability associated to high biocompatibility and safety, (b) have reduced risk of a host versus graft immune response, (c) mimic the local microenvironment for stem/precursor cell recruitment and differentiation, (d) monitor locally the functionality of the regenerated nerve cells to intervene with loco-regional therapies (e) perform local stimulation with tunable electric fields, (f) deliver locally growth factors, neurotransmitters, and drugs.
The use of flexible organic electronics devices (ultra-thin film organic field effect transistor (FET), organic electro-chemical transistor, nanoparticle organic memory FET) will advance the state-of-the-art of implantable devices for SCI from passive to active layouts that will promote nerve regeneration by a combination of local stimuli delivered on demand, will sense inflammation, and will control the immune-inflammatory response.
The biomedical impact of the project will be demonstrated in vitro and in vivo. In vitro, the neural therapeutic plasticity induced by the iONE-FP7 device will be evaluated on stem cells, which will be differentiated to neural progenitor cells, and then to neural cells. In vivo, the study of neural plasticity will be transferred to endogeneous stem cells by implanting the iONE-FP7 device into a contusion SCI animal model.
iONE-FP7 will acquire the knowledge and the technology required to regenerate the nerve in the niche of the injury.'