GENOMEDYNAMICS

Genome dynamics of the human fungal pathogen Candida albicans

Coordinatore	TEL AVIV UNIVERSITY    more  Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 contact info Titolo: Ms. Nome: Lea Cognome: Pais Email: send email Telefono: 97236408774 Fax: 97236409697
Nazionalità Coordinatore	Israel [IL]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-CIG
Funding Scheme	MC-CIG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-10-01   -   2016-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TEL AVIV UNIVERSITY  Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 contact info Titolo: Ms. Nome: Lea Cognome: Pais Email: send email Telefono: 97236408774 Fax: 97236409697	IL (TEL AVIV)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'This CIG grant proposes will support the Integration of Professor Judith Berman, who is currently a Full Professor at the University of Minnesota, in the United States and who will move to a Full Professor position at Tel Aviv University. Professor Berman is a highly regarded research focusing on the biology of Candida albicans, an important fungal pathogen of humans. The work proposes to analyze the dynamic processes by which this fungal pathogen evolves resistance to currently used antifungal drugs. The two objectives are to: 1) to characterize the types of long-range changes that arise following exposure to an extreme stress (e.g., antifungal drug), including the mechanisms that give rise to them and the dynamics with which they appear and 2) to establish how specific genome changes affect the fitness/growth of individuals and the population either in the presence or in the absence of the drug. Subaims for objective 1 will include: developing and adapting tools for the analysis of genome structure, including detection of long-range events and visualization of ultra high resolution sequencing data; Constructing sophisticated genetic strains; Identifying growth conditions and genetic factors that affect the frequency of specific genome changes; identifying and characterizing rare isolates that undergo multiple genome changes; and following the dynamics of the evolution drug resistance. Subaims for objective 2 will include: optimizing assays measurement of fitness/growth of individuals and populations over time; and comparing the fitness/growth of strains that acquired different genome changes. These objectives and subaims will facilitate the integration of Prof. Berman into the European Community of Life Sciences through her interdisciplinary approach to analyzing genome changes and studying the dynamics of the mechanisms through which they arise.'