TARGETBRAIN
Targeting Brain Inflammation For Improved Functional Recovery in Acute Neurodegenerative Disorders
| Coordinatore |
Organization address
address: Paradisgatan 5c contact info |
| Nazionalità Coordinatore | Non specificata |
| Sito del progetto | http://www.targetbrain.eu/ |
| Totale costo | 15˙716˙317 € |
| EC contributo | 11˙989˙162 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH- |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-12-01 - 2016-11-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
LUNDS UNIVERSITET
Organization address
address: Paradisgatan 5c contact info |
SE (LUND) | coordinator | 2˙132˙786.00 |
| 2 |
WEIZMANN INSTITUTE OF SCIENCE
Organization address
address: HERZL STREET 234 contact info |
IL (REHOVOT) | participant | 1˙594˙223.00 |
| 3 |
UNIVERSITAET ZUERICH
Organization address
address: Raemistrasse 71 contact info |
CH (ZURICH) | participant | 1˙461˙540.00 |
| 4 |
GOETEBORGS UNIVERSITET
Organization address
address: VASAPARKEN contact info |
SE (GOETEBORG) | participant | 1˙461˙510.00 |
| 5 |
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Organization address
address: Hofgartenstrasse 8 contact info |
DE (MUENCHEN) | participant | 1˙455˙945.00 |
| 6 |
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
Organization address
address: Cranmer Terrace contact info |
UK (LONDON) | participant | 1˙431˙600.00 |
| 7 |
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Organization address
address: Via Olgettina 58 contact info |
IT (MILANO) | participant | 1˙364˙200.00 |
| 8 |
GEMAC
Organization address
address: LIEU DIT BERGANTON contact info |
FR (SAINT JEAN D ILLAC) | participant | 587˙378.00 |
| 9 |
IMMUNOBRAIN LTD
Organization address
address: PEKRIS STREET 3 contact info |
IL (REHOVOT) | participant | 499˙980.00 |
| 10 |
PRONEURON BIOTHECHNOLOGIES (ISRAEL) LTD
Organization address
address: AHUZA STREET 45 contact info |
IL (RAANANA) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'In acute neurodegenerative disorders, following a sudden insult, neurons are rapidly damaged and usually die but cellular loss can occur hours and days thereafter. These diseases cause massive morbidity and mortality and tremendous economic and societal burden, especially ischemic stroke, which is a leading cause of death and disability with no effective treatment to promote recovery. The brain responds to a stroke, i.e., occlusion of a cerebral artery, with an inflammatory process characterized by rapid activation of resident cells including microglia and astrocytes, production of proinflammatory mediators, and infiltration of various types of immune cells. Recent studies have suggested that the local inflammation is not only detrimental but can also be beneficial for the repair process. Our proposal unites 7 leading academic teams and 2 experienced SMEs and aims to develop a pre-clinical protocol for immunomodulation leading to enhancement of cellular plasticity and improved functional recovery in stroke patients. To achieve this goal we will study the temporal and spatial role of inflammatory cells in stroke-induced brain damage and determine the action of inflammatory cells in the activation and support of regenerative processes, including the formation of new neurons from endogenous and transplanted neural stem cells (NSCs). We will investigate the ability of transplanted NSCs to modulate the inflammatory response and to affect the characteristics of the stroke-induced lesion and subsequent recovery. The overriding social objective of our project is to develop a novel therapeutic strategy which will shorten the recovery phase, minimize the motor impairments, and improve the patients’quality of life after stroke.'
Introduzione (Teaser)
Stroke affects 15 million people globally, out of which 5 million die and 5 million are permanently disabled. EU-funded researchers are working on finding solutions for facilitating recovery after stroke.