ACSAC

Aza-Claisen-Sakurai Approach to Cyclopentylamines

Coordinatore	QUEEN'S UNIVERSITY BELFAST    more  Organization address address: University Road city: BELFAST postcode: BT7 1NN contact info Titolo: Ms. Nome: Pauline Cognome: Mccann Email: send email Telefono: +44 28 90973229
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	209˙033 €
EC contributo	209˙033 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IIF
Funding Scheme	MC-IIF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-07-04   -   2014-07-03

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	QUEEN'S UNIVERSITY BELFAST  Organization address address: University Road city: BELFAST postcode: BT7 1NN contact info Titolo: Ms. Nome: Pauline Cognome: Mccann Email: send email Telefono: +44 28 90973229	UK (BELFAST)	coordinator	209˙033.40

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 Obiettivo del progetto (Objective)

'Cyclopentylamines are ubiquitous compounds within nature and many pharmaceutical products. Their synthesis can be problematic with length and unselective sequences plaguing them. We aim to overcome this shortcoming by developing a new approach whereby we couple two well known reactions; the Aza-Claisen (or Aza-Cope) rearrangement and the Sakurai allylation. The expected outcomes of this research are a new method which is both rapid and selective for the synthesis of cyclopentylamines. We also intend to achieve the total synthesis of the compound (-)-Altemicidin, a highly substituted cyclopentylamine which exhibits potent antitumor and acaricidal properties. Any compounds produced will be screened against various disease states either here at Queen’s using the Centre for Cancer Research and Cell Biology or with our academic and industrial partners.'