VOLTAGE-PROBE

Optical Probes for Membrane Potential via Photoinduced Electron Transfer

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD    more  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Gill Cognome: Wells Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	200˙371 €
EC contributo	200˙371 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-07-01   -   2014-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Gill Cognome: Wells Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801	UK (OXFORD)	coordinator	200˙371.80

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 Obiettivo del progetto (Objective)

'This project is concerned with supramolecular chemistry and the molecular engineering of optical fluorescent probes for sensing the voltages across plasma membranes in excitable cells such as neurones. The project is a combination of molecular design, organic synthesis, physical organic chemistry, spectroscopy and photobiology. The idea is to establish a competition between fluorescence and photoinduced electron transfer; the relative rates of these two processes will be sensitive to the electric field, thus the brightness of the fluorescence will provide a map of the voltage.

The project builds on three areas of expertise in Anderson’s group: (a) synthesis and photophysics of functional dyes; (b) molecular wires and (c) design and synthesis of probes for membrane potential in lipid bilayers based on second harmonic generation.

Patrik Neuhaus has an exceptionally strong background in spectroscopy and physical organic chemistry. He also has the knowledge of organic synthesis to make rapid progress with this project. However he has no previous experience of investigating the behavior of compounds in lipid membranes. This project will provide him with high-level training in an important and topical field, while enabling him to broaden his horizons.'

Introduzione (Teaser)

The same molecule found in haemoglobin and chlorophyll could be the basis of tomorrow's optoelectronics and magnetic data storage devices. EU-funded researchers characterised novel architectures to push the technology forward.