CCING
Cadherin control of invasive growth in morphogenesis and cancer
| Coordinatore | STICHTING KATHOLIEKE UNIVERSITEIT
Organization address
address: GEERT GROOTEPLEIN NOORD 9 contact info |
| Nazionalità Coordinatore | Netherlands [NL] |
| Totale costo | 255˙069 € |
| EC contributo | 255˙069 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2011-IIF |
| Funding Scheme | MC-IIF |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-01-01 - 2014-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
STICHTING KATHOLIEKE UNIVERSITEIT
Organization address
address: GEERT GROOTEPLEIN NOORD 9 contact info |
NL (NIJMEGEN) | coordinator | 255˙069.40 |
Mappa
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Obiettivo del progetto (Objective)
'Cadherin-based cell-cell junctions regulate tissue architecture by coordinating multicellular growth and polarity. In addition to the ubiquitously expressed and widely studied E-cadherin, epithelia express other, more tissue-specific classical cadherins, often particularly during developmental epithelial rearrangements. These additional cadherins recently also have been implicated in tumor progression, but their expression and function is poorly understood.
I recently demonstrated that different classical cadherin subtypes have distinct roles in branching morphogenesis. I hypothesize that cell-cell junction control in invasive growth of developmental branching morphogenesis is recapitulated in collective cancer invasion, where tumor cells invade as strands that maintain cadherin-based cell-cell contacts. The aim is therefore to determine how stage-dependent regulation of distinct cadherins control these processes, using the following objectives:
1. To test that co-expression of E-cadherin and other cadherins control cell migration and rearrangement of the extracellular matrix and, thus, invasive physiological growth.
2. To define the role of co-expressed cadherins in collective invasive growth and resistance in cancer.
To demonstrate how cadherins accessory to E-cadherin control physiological collective invasion and growth, and how this is recapitulated in an aberrant fashion during invasive growth of epithelial cancers, I will contrast models for branching morphogenesis of kidney and mammary epithelium to neoplastic invasion of kidney and breast cancer cells.'