CCING

Cadherin control of invasive growth in morphogenesis and cancer

Coordinatore	STICHTING KATHOLIEKE UNIVERSITEIT    more  Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ contact info Titolo: Mr. Nome: Maarten Cognome: Van Langen Email: send email Telefono: +31 243619791
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	255˙069 €
EC contributo	255˙069 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IIF
Funding Scheme	MC-IIF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-01-01   -   2014-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	STICHTING KATHOLIEKE UNIVERSITEIT  Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ contact info Titolo: Mr. Nome: Maarten Cognome: Van Langen Email: send email Telefono: +31 243619791	NL (NIJMEGEN)	coordinator	255˙069.40

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 Obiettivo del progetto (Objective)

'Cadherin-based cell-cell junctions regulate tissue architecture by coordinating multicellular growth and polarity. In addition to the ubiquitously expressed and widely studied E-cadherin, epithelia express other, more tissue-specific classical cadherins, often particularly during developmental epithelial rearrangements. These additional cadherins recently also have been implicated in tumor progression, but their expression and function is poorly understood.

I recently demonstrated that different classical cadherin subtypes have distinct roles in branching morphogenesis. I hypothesize that cell-cell junction control in invasive growth of developmental branching morphogenesis is recapitulated in collective cancer invasion, where tumor cells invade as strands that maintain cadherin-based cell-cell contacts. The aim is therefore to determine how stage-dependent regulation of distinct cadherins control these processes, using the following objectives:

1. To test that co-expression of E-cadherin and other cadherins control cell migration and rearrangement of the extracellular matrix and, thus, invasive physiological growth.

2. To define the role of co-expressed cadherins in collective invasive growth and resistance in cancer.

To demonstrate how cadherins accessory to E-cadherin control physiological collective invasion and growth, and how this is recapitulated in an aberrant fashion during invasive growth of epithelial cancers, I will contrast models for branching morphogenesis of kidney and mammary epithelium to neoplastic invasion of kidney and breast cancer cells.'