RE-LIVER

Bottom-up reconstitution of a biomimetic bioartificial liver

Coordinatore	UNIVERSITA DI PISA    more  Organization address address: Lungarno Pacinotti 43/44 city: PISA postcode: 56126 contact info Titolo: Dr. Nome: Immacolata Cognome: Viva Email: send email Telefono: +39 050 2217833 Fax: +39 050 2217051
Nazionalità Coordinatore	Italy [IT]
Totale costo	5˙377˙150 €
EC contributo	4˙234˙877 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2012-INNOVATION-2
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-07-01   -   2015-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITA DI PISA  Organization address address: Lungarno Pacinotti 43/44 city: PISA postcode: 56126 contact info Titolo: Dr. Nome: Immacolata Cognome: Viva Email: send email Telefono: +39 050 2217833 Fax: +39 050 2217051	IT (PISA)	coordinator	824˙999.00
2	MEDICYTE GMBH  Organization address address: Im Neuenheimer Feld 581 city: Heidelberg postcode: 69120 contact info Titolo: Mr. Nome: Stefan Cognome: Holder Email: send email Telefono: 4962220000000 Fax: 4962220000000	DE (Heidelberg)	participant	1˙738˙180.00
3	THE UNIVERSITY OF MANCHESTER  Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL contact info Titolo: Dr. Nome: Katherine Cognome: Boylan Email: send email Telefono: +44 161 2758796 Fax: +44 161 2752445	UK (MANCHESTER)	participant	763˙152.00
4	THE ELECTROSPINNING COMPANY LTD  Organization address address: WATERMARK WAY 10 city: HERTFORD postcode: SG13 7TZ contact info Titolo: Ms. Nome: Ann Cognome: Kramer Email: send email Telefono: +44 845 2693495	UK (HERTFORD)	participant	559˙356.00
5	GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O  Organization address address: Oskar-von-Miller-Ring 29 city: MUENCHEN postcode: 80333 contact info Titolo: Ms. Nome: Birgit Cognome: Fuchs Email: send email Telefono: +49 89 28810414 Fax: +49 89 28810420	DE (MUENCHEN)	participant	349˙190.00

Mappa

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 Obiettivo del progetto (Objective)

'The liver, by way of its central role in both endogenous and exogenous metabolism, is one of the most well-studied organs in the human body. Hepatic tissue and its derivatives have a wide range of in-vivo and in-vitro applications from whole organ or partial lobe transplant, bioartificial ex-vivo devices, treatment of metabolic disorders to toxicology, drug metabolism and tissue regeneration. On the one hand, suitable donor livers for solid organ transplant are in short supply, while chronic liver diseases are on the increase both in Europe and world-wide. On the other hand, in-vitro and ex-vivo technologies for recapitulating liver function still fall short of reliability, consistency and predictivity, precluding many commercial applications. There is a dire need for innovative and reproducible methods for developing functional bioartificial livers or portions of liver which can be easily transplanted or reliably integrated into extracorporeal devices, essential for treating acute liver failure and other metabolic liver disorders. To avoid the risks and complications associated with animal/human matrices, yet furnish a reliable and reproducible 3D microarchitecture capable of maintaining the detoxification and metabolic functions of healthy human liver, our aim is to fabricate a novel hepatic lobuli ECM replica seeded with stable human hepatocytes and endothelial cells using the human liver as a design template through a bottom up approach. These cell-containing bioartificial constructs will be developed and characterized in vitro to assess metabolic function, protein production and angiogenic potential. They will then be implanted in animal models through minimally invasive techniques as a solid organ transplant alternative to recombinant Factor VIII-based therapy for patients with haemophilia A.'