NANOMAL

Development of a handheld antimalarial drug resistance diagnostic device using nanowire technology

Coordinatore	ST GEORGE'S HOSPITAL MEDICAL SCHOOL    more  Organization address address: Cranmer Terrace city: LONDON postcode: SW17 0RE contact info Titolo: Ms. Nome: Jane Cognome: Boland Email: send email Telefono: +44 20 8266 6818
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	5˙236˙310 €
EC contributo	3˙992˙150 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2012-INNOVATION-2
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-07-01   -   2015-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ST GEORGE'S HOSPITAL MEDICAL SCHOOL  Organization address address: Cranmer Terrace city: LONDON postcode: SW17 0RE contact info Titolo: Ms. Nome: Jane Cognome: Boland Email: send email Telefono: +44 20 8266 6818	UK (LONDON)	coordinator	994˙655.00
2	QuantuMDx Group Limited  Organization address address: Hartley Way 9 city: Surrey postcode: CR8 4EJ contact info Titolo: Mrs. Nome: Elaine Cognome: Warburton Email: send email Telefono: +44 7 912206106 Fax: +44 8 708030999	UK (Surrey)	participant	2˙629˙416.00
3	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Dr. Nome: Miles Cognome: Davies Email: send email Telefono: 46852486593	SE (STOCKHOLM)	participant	195˙879.00
4	EBERHARD KARLS UNIVERSITAET TUEBINGEN  Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 contact info Titolo: Dr. Nome: Carsten Cognome: Köhler Email: send email Telefono: +49 7 0712982366 Fax: +49 7 071294684	DE (TUEBINGEN)	participant	172˙200.00

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 Obiettivo del progetto (Objective)

'Malaria is a global health priority that has been targeted for elimination in recent years. Attaining the goals that define elimination of malaria in different countries depends critically on provision of effective antimalarials and further that these antimalarials are used appropriately in individual patients. Drug resistance is a major threat to malaria control and has important global public health implications. Over the past decades the genetic bases for resistance to most of the antimalarial classes currently in use has become defined. For some drugs and combinations, these mutations are the most important predictors of treatment failure. This proposal will innovate new technologies to confirm malaria diagnosis and detect drug resistance in malaria parasites by analysis of mutations in nucleic acids, using nanowire technology, and will result in the development of a simple, rapid and affordable point-of-care handheld diagnostic device. The device will be useful at many levels in malarial control by:

1. Optimising individual treatments for patients 2. Assessing the epidemiology of drug resistance in malaria endemic areas 3. Assessing population impacts of antimalarial interventions

The development programme capitalises on highly original and proprietary advances made by QuantuMDx in the field of point-of-care diagnostics. This is complemented by academic expertise that has made major contributions to the understanding of antimalarial drug resistance mechanisms in laboratory models, as well as parasites obtained directly from patients. The impact of this proposal can be extended rapidly to other established and emerging infectious diseases.'

Introduzione (Teaser)

Drug resistance is one of the most important factors in malaria treatment failure, often with deadly consequences. A pioneering cell phone-type device that analyses infection and malarial mutations with a finger prick could save billions of lives.