INSANE IN A MEMBRANE

The origin and function of CD20 positive T-cells in health and disease

Coordinatore	THE UNIVERSITY OF EXETER    more  Organization address address: Northcote House, The Queen's Drive city: EXETER postcode: EX4 4QJ contact info Titolo: Ms. Nome: Gaynor Cognome: Hughes Email: send email Telefono: +44 1392 725835 Fax: +44 1392 263686
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	104˙516 €
EC contributo	104˙516 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	0
Periodo (anno-mese-giorno)	0000-00-00   -   0000-00-00

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EXETER  Organization address address: Northcote House, The Queen's Drive city: EXETER postcode: EX4 4QJ contact info Titolo: Ms. Nome: Gaynor Cognome: Hughes Email: send email Telefono: +44 1392 725835 Fax: +44 1392 263686	UK (EXETER)	coordinator	104˙516.70

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 Obiettivo del progetto (Objective)

'The expression of CD20 is generally assumed to be restricted to lymphocytes of the B-cell lineage. However, there is accumulating evidence that a small subpopulation of T-cells also express CD20. These CD20 T-cells, which might be described as “insane in their membrane”, were first reported in 1993. The role of these cells in the immune system, however, has never been addressed. The preliminary data presented in the current proposal indicates that the vast majority of these CD20 T-cells are in fact effector memory T-cells (TEM). Moreover, preliminary data implicate these CD20 TEM cells in the pathogenesis of Rheumatoid Arthritis (RA) and Ovarian Cancer (OC). In RA patients, these CD20 TEM cells secrete large amounts of the pro-inflammatory cytokine IL-17. In OC patients, CD20 TEM cells account for a striking 20% of all resident T-cells in the peritoneal fluid of patients. Taken together, these findings suggest that CD20 TEM cells may represent a thus far neglected, but important, immune cell population involved in the pathogenesis of major human diseases like auto-immunity and cancer. The aim of the current proposal is to determine the origin and function of CD20 TEM cells in healthy individuals, and determine their involvement in auto-immune and cancer progression. To this end, we will determine the precise phenotype of CD20 TEM cells, their broad antigen-specificity, and changes that occur within this population during RA/OC progression. In addition, we will determine if CD20 T-cells can be induced from naive T-cells. Finally, we will perform preliminary experiments to determine whether CD20 T-cells might be used for cancer immunotherapy, or selectively eliminated for treatment of auto-immune disease.'