DEAROMATIZATION

New Dearomatization Methods for Chemical Synthesis and Synthetic Biology

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	221˙606 €
EC contributo	221˙606 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IIF
Funding Scheme	MC-IIF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-03-01   -   2015-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988	UK (CAMBRIDGE)	coordinator	221˙606.40

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 Obiettivo del progetto (Objective)

'The hypothesis behind our synthesis blueprint involves the development of new dearomatization process that comprises phenol oxidative dearomatization and organocatalytic desymmetrization, generating highly functionalized, non-racemic architectures. A key aspect of this process is the formation of quaternary centres embedded within a complex structural framework containing valuable orthogonal functionality. With this in mind, we have identified classes of molecules that could be accessed through exploitation and developments of this methodology. The natural product targets encompass structures of alkaloids such as morphine, as well as complex non-natural frameworks that may have interesting properties as the basis for novel small-molecule libraries. Also we have identified that dearomatization could be a useful tool in synthetic biology wherein tyrosine residues are targets for selective oxidation and conjugated with a suitable reagent of function. This will lead to an exciting new tool for chemical biology. The overall proposal is split into three objective research plans comprising (i) the development of CED methodology (ii) the synthesis of morphine, and (iii) the development of deraromatization methods for synthetic biology.'

Introduzione (Teaser)

Organic chemists have developed and tested a new method that will reduce the cost of creating important chemicals like morphine.

Descrizione progetto (Article)

The modern chemical industry is constantly searching for new pathways and methods to produce complex organic molecules. In particular, there is a need for means to produce naturally occurring molecules to replace unsustainable exploitation of natural resources.

To take steps towards addressing this problem, the EU funded the 'New dearomatization methods for chemical synthesis and synthetic biology' (DEAROMATIZATION) project. Researchers aimed to test one such method of chemical synthesis.

The method, known as catalytic enantioselective dearomatisation (CED), was conceived before the project began but had not been tested yet.

DEAROMATIZATION first identified potential classes of molecules that could be created using CED; these included morphine and a chemical framework for creating other compounds. Researchers spent much of the project perfecting the experimental method, using morphine as a model product of the CED method.

Project research also showed that CED produces side-products with potential value as building blocks for other molecules.

The new CED methodology may provide industrial chemists with a direct route of synthesis for a range of naturally occurring molecules. In addition, the method could allow them to produce entirely novel molecules and compounds.