OPTOBACTERIA
Multianalyte automatic system for the detection of drug resistant bacteria
| Coordinatore | TYDOCK PHARMA S.r.l
Organization address
address: Strada Gherbella 294/b contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Totale costo | 1˙626˙952 € |
| EC contributo | 1˙250˙700 € |
| Programma | FP7-SME
Specific Programme "Capacities": Research for the benefit of SMEs |
| Code Call | FP7-SME-2011 |
| Funding Scheme | BSG-SME |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-11-01 - 2014-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
TYDOCK PHARMA S.r.l
Organization address
address: Strada Gherbella 294/b contact info |
IT (Modena) | coordinator | 483˙428.00 |
| 2 |
OPTOSMART SRL
Organization address
address: VIA PONTANO 61 contact info |
IT (NAPOLI) | participant | 369˙080.00 |
| 3 |
PROYECCION EUROPLAN XXI S.L.
Organization address
address: POLIGONO INDUSTRIAL CAMPO ALTO NAVE 118 contact info |
ES (ELDA ALICANTE) | participant | 171˙000.00 |
| 4 |
MOLECULAR DISCOVERY LTD
Organization address
address: MARSH ROAD 215 PINNER contact info |
UK (London) | participant | 167˙000.00 |
| 5 |
CONSIGLIO NAZIONALE DELLE RICERCHE
Organization address
address: Piazzale Aldo Moro 7 contact info |
IT (ROMA) | participant | 13˙392.00 |
| 6 |
Centro Regionale Information Communication Technology scrl
Organization address
address: Viale Traiano Palazzo ex Poste Snc contact info |
IT (Benevento) | participant | 12˙800.00 |
| 7 |
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Organization address
address: VIA UNIVERSITA 4 contact info |
IT (MODENA) | participant | 12˙800.00 |
| 8 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 11˙694.63 |
| 9 |
FUNDACION PUBLICA ANDALUZA PARA LAGESTION DE LA INVESTIGACION EN SALUD DE SEVILLA
Organization address
address: AVENIDA MANUEL SIUROT contact info |
ES (SEVILLA) | participant | 9˙505.37 |
Mappa
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Obiettivo del progetto (Objective)
'Infectious disease are responsible of high human health burden and cost. Time to diagnosis release and quality of the microrganism detection represent an area of interest for optical fiber based device application. OPTObacteria propose an highly expert consortium in which 4 SME and 4 research peformers from 3 European countries would synergize their efforts to provide a unique Automatic Laboratory Detector (ALD) to deliver a drug resistance report in a 4 or 4-8 hours timeframe. The time is depending on the experiment required, it avoid bacterial grwoth time, typical of the antibiogram typical report and provide an detection up to low ng concentration or even low. With respect to other optical-based device (like SPR, surface plamon resosnance) many limitations are overcome.'
Introduzione (Teaser)
EU-funded researchers are building a cheap and simple handheld device that can detect drug-resistant bacteria in a matter of hours.
Descrizione progetto (Article)
Antibiotic resistance is a growing problem in hospitals, and the phenomenon is already responsible for an increased disease burden globally. Currently, detecting these bacteria requires expensive and time-consuming laboratory methods.
The 'Multianalyte automatic system for the detection of drug resistant bacteria' (http://www.optobacteria.eu (OPTOBACTERIA)) project aims to develop an automatic laboratory detector (ALD) device that can provide a drug-resistance report in 4 to 8 hours. This will be achieved using recently developed fibre-optic technology.Project members have designed and developed a nano-scale fibre-optic transducer to convert the biological signal into an optical signal. Prototypes of the transducer were produced and successfully tested.
Libraries of molecules were screened for use as sensors for beta-lactamase (a common indicator of antibiotic resistance), and 20 potential sensors were selected. Further, researchers have anchored two of these to a prototype probe and successfully detected the presence of beta-lactamase.Future efforts will entail building an ALD prototype and testing the device in small-scale clinical trials. If successful, the device will help decrease the health impact of antibiotic resistance and contribute to epidemiological research.