PATHCO

"Pathogen COinfection: HIV, Tuberculosis, Malaria and Hepatitis C virus"

Coordinatore	THE UNIVERSITY OF LIVERPOOL    more  Organization address address: Brownlow Hill, Foundation Building 765 city: LIVERPOOL postcode: L69 7ZX contact info Titolo: Ms. Nome: Cate Cognome: Cowton Email: send email Telefono: +44 151 794 8735 Fax: +44 151 794 8728
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	7˙824˙811 €
EC contributo	5˙909˙690 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2012-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-11-01   -   2017-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF LIVERPOOL  Organization address address: Brownlow Hill, Foundation Building 765 city: LIVERPOOL postcode: L69 7ZX contact info Titolo: Ms. Nome: Cate Cognome: Cowton Email: send email Telefono: +44 151 794 8735 Fax: +44 151 794 8728	UK (LIVERPOOL)	coordinator	891˙688.93
2	THE UNIVERSITY OF BIRMINGHAM  Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT contact info Titolo: Ms. Nome: May Cognome: Chung Email: send email Telefono: 441214000000 Fax: 441214000000	UK (BIRMINGHAM)	participant	1˙277˙757.00
3	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Tatjana Cognome: Palalic Email: send email Telefono: +44 207 594 6265	UK (LONDON)	participant	987˙597.60
4	INSTITUT PASTEUR  Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 contact info Titolo: Dr. Nome: Marie-Laure Cognome: Rosso Email: send email Telefono: +33 1 45 68 95 26	FR (PARIS CEDEX 15)	participant	960˙000.00
5	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Mrs. Nome: Isabelle Cognome: Verdier Email: send email Telefono: +331 48 07 34 33 Fax: +331 48 07 34 26	FR (PARIS)	participant	450˙468.40
6	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Linda Cognome: Pialek Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801	UK (OXFORD)	participant	400˙548.00
7	UNIVERSITY OF CAPE TOWN  Organization address address: PRIVATE BAG X3 city: RONDEBOSCH postcode: 7701 contact info Titolo: Prof. Nome: Robert John Cognome: Wilkinson Email: send email Telefono: +27 21 406 6084 Fax: +27 21 406 6796	ZA (RONDEBOSCH)	participant	377˙914.00
8	UNIVERSITAETSKLINIKUM FREIBURG  Organization address address: HUGSTETTER STRASSE 49 city: FREIBURG postcode: 79106 contact info Titolo: Ms. Nome: Maren Cognome: Mihlan Email: send email Telefono: +49 761 27084420 Fax: +49 761 27018890	DE (FREIBURG)	participant	374˙519.00
9	ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU  Organization address address: VIA FIORENTINA 151 city: SIENA postcode: 53100 contact info Titolo: Dr. Nome: Riccardo Cognome: Bertini Email: send email Telefono: +39 0577 50518 Fax: +39 0862 318967	IT (SIENA)	participant	144˙000.00
10	Academisch Medisch Centrum bij de Universiteit van Amsterdam  Organization address address: MEIBERGDREEF 9 city: AMSTERDAM postcode: 1105AZ contact info Titolo: Mr. Nome: Frank Cognome: Groen Email: send email Telefono: +31 20 56 63198	NL (AMSTERDAM)	participant	45˙197.07
11	CHINA NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH CO LTD  Organization address address: HA LEI ROAD 8 LANE 898 city: SHANGHAI postcode: 201203 contact info Titolo: Mr. Nome: Andrew Cognome: Natenshon Email: send email Telefono: +86 21 61606378	CN (SHANGHAI)	participant	0.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Acquired immune deficiency (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. In addition to these pathogens, 170 million people are infected with hepatitis C virus (HCV), which leads to chronic liver disease. Because of shared routes of transmission, HCV co-infection is recognized as a major cause of morbidity and mortality among HIV-1 infected persons. The epidemiology and clinical features of co-infected subjects are well documented, however, there is a paucity of basic scientific studies addressing the interactions between these pathogens. There is undoubtedly a complex interplay between pathogens and the host immune response. This was highlighted when the Merck HIV-1 vaccine trial was halted due to increased HIV-1 transmission amongst vaccine recipients with previous adenovirus infection, suggesting that immune responses specific for adenovirus vector antigens were detrimental. We propose that pathogen evasion and dysregulation of host immune responses plays a key role in co-infection associated morbidity. We will test this hypothesis by establishing in vitro and ex vivo co-infection model systems to study pathogen interactions and assess the effect(s) of co-infection on innate signalling and adaptive immune responses. We will develop new approaches to dissect pathogen interactions, ranging from the genesis of fluorescent labelled viruses to state-of-the-art tissue explant models and novel humanised mouse models. Translational studies of co-infected patients will ascertain pathogen-specific effects on innate and adaptive immune responses and the consequences for disease progression. It is imperative that such interactions are elucidated before proceeding with new prophylactic or therapeutic strategies aimed at curtailing pathogen transmission or disease progression in co-infected individuals. We specifically address the call of understanding the basic biology of co-pathogen interactions and immunity.'