LYMPHOONCOGENOMICS

Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers

Coordinatore	INSTITUT PASTEUR    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	France [FR]
Totale costo	1˙498˙940 €
EC contributo	1˙498˙940 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2012-StG_20111109
Funding Scheme	ERC-SG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-02-01   -   2018-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT PASTEUR  Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 contact info Titolo: Dr. Nome: Ludovic Gérard Marie Cognome: Deriano Email: send email Telefono: +33 1 44 38 93 55 Fax: +33 1 44 38 93 55	FR (PARIS CEDEX 15)	hostInstitution	1˙498˙940.00
2	INSTITUT PASTEUR  Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 contact info Titolo: Dr. Nome: Marie-Laure Cognome: Rosso Email: send email Telefono: +33 1 44 38 95 26 Fax: +33 1 40 61 39 40	FR (PARIS CEDEX 15)	hostInstitution	1˙498˙940.00

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 Obiettivo del progetto (Objective)

'Lymphoid cancers are among the most common human malignancies and characteristically harbour genomic aberrations. Although databases will soon be flooded with genome sequences from thousands of tumours, interpretation and validation of these data is limited by the genetic variability and uncontrolled environmental exposures inherent to human studies. There is therefore a growing need in complementary approaches that would provide understanding of how and which genomic aberrations underlie tumour genesis. It has become apparent that the generation of DNA double strand breaks during the process of antigen receptor diversification, including RAG1/2 protein-generated DNA breaks during V(D)J recombination, are key intermediates in the appearance of lymphoid neoplasm. In this project, we propose to elucidate the molecular mechanisms, the genomic lesions and the oncogenic pathways underlying B and T cell cancers using a combination of mouse models and cutting-edge cytogenetic, genomic and transcriptomic technologies. We aim (i) to define the major genomic lesions and oncogenic pathways underlying the rapid onset of T-cell lymphomas in a unique mouse model that carries exacerbated RAG-induced genomic instability; (ii) to decipher the genomic lesions and pathways underlying B versus T lymphoma tropism; (iii) to investigate the functional interactions between RAG- and DNA damage response / DNA repair-complexes in suppressing genomic instability and lymphomagenesis; and (iv) to identify and validate lesions and genes underlying human B and T cell cancers using a cross-species oncogenomic comparative approach. In doing so, this study will also 1) increase our understanding of the fundamental mechanisms maintaining genome stability during lymphocyte development; 2) greatly improve interpretation and validation of whole genome sequencing analysis of human leukaemia and lymphoma; and 3) provide well-characterized animal models for developing and testing targeted therapeutics.'