MOD-ENP-TOX
Modeling Assays Platform "MAP" for hazard ranking of engineered nanoparticles (ENPs)
| Coordinatore | KATHOLIEKE UNIVERSITEIT LEUVEN
Organization address contact info |
| Nazionalità Coordinatore | Belgium [BE] |
| Totale costo | 1˙385˙240 € |
| EC contributo | 1˙000˙000 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2012-SMALL-6 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-01-01 - 2015-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 | KATHOLIEKE UNIVERSITEIT LEUVEN | BE | coordinator | 0.00 |
| 2 |
GENEDATA AG
Organization address
address: MARGARETHENSTRASSE 38 contact info |
CH (BASEL) | participant | 0.00 |
| 3 |
NATIONAL HEALTH RESEARCH INSTITUTES
Organization address
address: Keyan Road 35 contact info |
TW (ZHUNAN) | participant | 0.00 |
| 4 |
RHENOVIA PHARMA
Organization address
address: RUE DE CHEMNITZ 20C contact info |
FR (MULHOUSE) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
MOD-ENP-TOX project is a multidisciplinary project aiming to accomplish the following objectives: (i) to develop a novel and rational Modelling Assay Platform (MAP) which can be used as a « Risk Indicator » tool to predict the toxicity of metal-based NPs (MeNPs), and (ii) to demonstrate the feasibility of a MAP prototype on a shortlist of MeNPs - which can be further developed to screen the toxicity of a large number ENPs. Based on the concept of Integrating Testing Strategies (ITS), the proposed generic MAP combines two main and complimentary paradigms: (1) a novel Computational Modelling Package (CMP) based on structural, mechanistic, as well as kinetic modelling tools and (2) an innovative high content screening (HCS) strategy that allows performing multiplexed streamlined assays for calibration, refinement and validation of the computed models.
First a series of classification algorithms will be applied to identify MeNPs with similar toxicity patterns, then computational modelling tools will be developed to establish a more rational relationship between MeNPs descriptors and their toxicity in a dynamic and quantitative way. An in-vitro/in-vivo HCS paradigm will be developed as a scalable assessment tool to calibrate and validate the predictive power of the CMP using subsets of the training set or independent set of MeNPs (validation set) respectively.
Introduzione (Teaser)
The speed with which products incorporating nanomaterials are entering the market is tremendous, and many, many more are in the pipeline. High-throughput computational tools will soon be able to predict potential toxicity.