RISK - IR
"Risk, Stem Cells and Tissue Kinetics – Ionising Radiation"
| Coordinatore | Department of Health
Organization address
address: Quarry House, Quarry Hill contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 8˙597˙164 € |
| EC contributo | 6˙685˙000 € |
| Programma | FP7-EURATOM-FISSION
EURATOM: Nuclear fission and radiation protection |
| Code Call | FP7-Fission-2012 |
| Funding Scheme | CP |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-11-01 - 2017-04-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
Department of Health
Organization address
address: Quarry House, Quarry Hill contact info |
UK (Leeds) | coordinator | 1˙292˙548.00 |
| 2 |
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Organization address
address: RUE LEBLANC 25 contact info |
FR (PARIS 15) | participant | 2˙029˙427.00 |
| 3 |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address
address: Albinusdreef 2 contact info |
NL (LEIDEN) | participant | 622˙520.00 |
| 4 |
UNIVERSITY OF SUSSEX
Organization address
address: Sussex House contact info |
UK (FALMER, BRIGHTON) | participant | 481˙035.00 |
| 5 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | participant | 410˙000.00 |
| 6 |
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 contact info |
ES (MADRID) | participant | 399˙244.00 |
| 7 |
TECHNISCHE UNIVERSITAET DARMSTADT
Organization address
address: Karolinenplatz 5 contact info |
DE (DARMSTADT) | participant | 396˙480.00 |
| 8 |
UNIVERSITE LIBRE DE BRUXELLES
Organization address
address: Avenue Franklin Roosevelt 50 contact info |
BE (BRUXELLES) | participant | 391˙800.00 |
| 9 |
Nome Ente NON disponibile
Organization address
address: VIALE BENEDUCE 10 contact info |
IT (CASERTA) | participant | 344˙400.00 |
| 10 |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Organization address
address: Ingolstaedter Landstrasse 1 contact info |
DE (MUENCHEN) | participant | 294˙295.00 |
| 11 |
MEDICAL RESEARCH COUNCIL
Organization address
address: NORTH STAR AVENUE POLARIS HOUSE contact info |
UK (SWINDON) | participant | 23˙251.00 |
| 12 |
HEALTH PROTECTION AGENCY HPA
Organization address
address: Central Office - 7th Floor, Holborn Gate - High Holborn 330 contact info |
UK (LONDON) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'The magnitude of cancer risk in humans exposed to low radiation doses (<100mSv) is uncertain and depends upon extrapolation of human population based estimates obtained at higher doses. The linear non-threshold extrapolation model currently used has some support from mechanistic/biophysical considerations but it is not based on understanding of the biological responses of the cells of origin for radiation cancer. Stem cells are widely recognised as the cells of origin for many cancers. Understanding the responses of stem cells to low radiation doses will be important therefore in providing mechanistic support for low dose cancer risk extrapolation. In this project, techniques emerging from stem cell biological and tissue kinetics research will be used to address several major areas of uncertainty in low dose (<100 mGy) cancer risk estimates:
1. The identification and enumeration of stem/progenitor cells at risk 2. Understanding low dose radio-sensitivity of stem cells and tissues. 3. Improving understanding of mechanisms of age-dependant cancer risk 4. Improving understanding of tissue specific differences in cancer risk. 5. Identification of key events and individual susceptibility factors associated with cancer development.
The primary output of the RISK-IR project will be peer reviewed scientific papers. Considerable efforts will be made to consolidate scientific evidence of relevance for radiation protection through reviews and dissemination of project results and implications to radiation protection specialists will be facilitated through a stakeholder meeting in the final year of the project.'
Introduzione (Teaser)
Cancer risk in humans exposed to low radiation doses is usually calculated based upon estimates obtained at higher doses. As many cancers originate in stem cells, studying low dose radiation effects on these cells is particularly important.