NANOTRAC

Tracing the Intracellular Fate of Anticancer Nanomedicines

Coordinatore	UNIVERSITY OF STRATHCLYDE    more  Organization address address: Richmond Street 16 city: GLASGOW postcode: G1 1XQ contact info Titolo: Mr. Nome: Martin Cognome: Gregory Email: send email Telefono: +44 141 548 2524 Fax: +44 141 552 4409
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-CIG
Funding Scheme	MC-CIG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-03-01   -   2017-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF STRATHCLYDE  Organization address address: Richmond Street 16 city: GLASGOW postcode: G1 1XQ contact info Titolo: Mr. Nome: Martin Cognome: Gregory Email: send email Telefono: +44 141 548 2524 Fax: +44 141 552 4409	UK (GLASGOW)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Nanomedicines are defined as specifically engineered, nanosized drugs and drug delivery systems that are comprised of multiple components. For example, polymer-drug conjugates and drug-protein conjugates are emerging as promising approaches to treating a number of diseases, including cancer. The payloads of these nanomedicines differ widely. However, when targeting cancer, there is a universal requirement to reach the tumour microenvironment and often to deliver the payload to a specific intracellular compartment in order to yield the desired therapeutic effect. The goal of this proposal is to develop two complementary approaches that showcase the manufacturing of functionalised biopolymer-based nanoparticles and their subsequent biological evaluation in relation to cellular and subcellular trafficking in the tumour microenvironment. To achieve this goal, I propose two main aims. Aim 1 is to generate drug-loaded silk nanoparticles that can be readily functionlised to target specific cells and cellular compartments. I hypothesise that by using functionalised silk nanoparticles, it will be possible to target and deliver a therapeutic payload to cancer cells, which will lead to improved clinical outcomes in vivo. Aim 2 is to establish a repertoire of subcellular fractionation techniques in order to quantitatively describe the intracellular fate of nanomedicines in vitro and in vivo. I hypothesise that in particular, subcellular fractionation methods will allow a better understating of the fate of nanoparticles in tumour cells and their subsequent intracellular trafficking. Taken together, these studies will demonstrate an integrated approach to the development of next-generation nanomedicines. This proposal provides the drug delivery field with a novel nanoparticle system and a unique toolbox for the cellular tracing of nanomedicines for the wider scientific community.'