GELCRYS

A Supramolecular Gel Control of Pharmaceutical Crystal Growth

Coordinatore	UNIVERSITY OF DURHAM    more  Organization address address: STOCKTON ROAD THE PALATINE CENTRE city: DURHAM postcode: DH1 3LE contact info Titolo: Ms. Nome: Wendy Cognome: Harle Email: send email Telefono: +44 191 3344635 Fax: +44 191 3344634
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	309˙235 €
EC contributo	309˙235 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IIF
Funding Scheme	MC-IIF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-04-15   -   2015-04-14

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF DURHAM  Organization address address: STOCKTON ROAD THE PALATINE CENTRE city: DURHAM postcode: DH1 3LE contact info Titolo: Ms. Nome: Wendy Cognome: Harle Email: send email Telefono: +44 191 3344635 Fax: +44 191 3344634	UK (DURHAM)	coordinator	309˙235.20

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 Obiettivo del progetto (Objective)

'The solid form of drug substances (active pharmaceutical ingredients, API) is of huge importance to the European pharmaceutical industry and the European economy, which makes tremendous investments on crystal structure calculation and empirical polymorph screening. Different crystal forms (polymorphs, pseudopolymorphs, salts or co-crystals) have different bioavailability and solubility, and the crystal morphology significantly affects processing and tabletting behaviour. Here, we propose to develop a novel method for identifying, isolation and screening, of new drug solid forms, particularly the production of previously unknown polymorphs by use of chemically and physically tunable supramolecular gels. A gel fiber represents on the local scale an ordered and controllable array of chemical functionality suitable to act as a heteronucleating surface and hence influence the structure of a growing crystal nucleus of a drug polymorph. In well designed cases the API will bind to the gel in such a way that the short-range periodicity within a gel fibril can match up with a complementary face of a precritical nucleus of a particular solid form and hence stabilize that nucleus relative to homogeneous nucleation. Such ‘active’ gels are expected to catalyse the formation of otherwise unstable or hard-to-nucleate solid forms. This proposal aims to use low molecular weight gels as a medium for the templated growth of APIs and to take advantage of the supramolecular nature of these gels in order to dissolve them and hence recover the crystals. The principal objectives are three fold: (i) Tailor specific gelators to complement the functional groups of target APIs in order to template the growth of novel solid forms by specific solute-gelator molecular recognition. (ii) Establish reversible gelation condition in order to recover the APIs by dissolving the gels. (iii) Show by means of relevant case studies that tailored gelators allow the discovery of novel drug solid forms.'