METDEF

Metabolic engineering of triterpenoid pathways involved in plant defense in Arabidopsis and rice

Coordinatore	JOHN INNES CENTRE    more  Organization address address: "Norwich Research Park, Colney" city: NORWICH postcode: NR4 7UH contact info Titolo: Dr. Nome: Mary Cognome: Anderson Email: send email Telefono: +44 1603 450244 Fax: +44 1603 450045
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	221˙606 €
EC contributo	221˙606 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IEF
Funding Scheme	MC-IEF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-03-04   -   2015-03-03

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	JOHN INNES CENTRE  Organization address address: "Norwich Research Park, Colney" city: NORWICH postcode: NR4 7UH contact info Titolo: Dr. Nome: Mary Cognome: Anderson Email: send email Telefono: +44 1603 450244 Fax: +44 1603 450045	UK (NORWICH)	coordinator	221˙606.40

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 Obiettivo del progetto (Objective)

'Plants produce a diversity array of natural products (otherwise known as secondary metabolites) that have important ecological functions (Dixon 2001; Field and Osbourn 2008). Triterpenes are one of the largest classes of plant-derived natural products. These compounds protect plants against pests and diseases and are also important as drugs and anticancer agents (Papadopoulou et al 1999; Phillips et al 2006; Liby et al 2007). Arabidopsis and also cereals such as rice do not make protective triterpene glycosides (Hostettmann & Marston, 1995; Vincken et al 2007). These model species are therefore excellent experimental systems for proof-of-concept experiments involving metabolic engineering of triterpene pathways into heterologous species. The aim of this proposal is to engineer triterpene metabolic pathways into Arabidopsis and rice by genetic modification. As part of this work I will develop methods for introducing multiple genes into plants using recombineering and synthetic biology approaches. At the end of this project we will have the necessary knowledge to devise strategies to introduce multiple genes into diverse plant species for control of plant pests and diseases based on synthesis of protective triterpenes.'