MANIPULATENEURALCODE

"Determination of the neural code, or how the brain processes and stores information, by recording and stimulating neural activity in awake behaving mice"

 Coordinatore UNIVERSITY COLLEGE LONDON 

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Malgorzata
Cognome: Kielbasa
Email: send email
Telefono: 4420310000000
Fax: 442078000000

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 231˙283 €
 EC contributo 231˙283 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-07-01   -   2015-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Malgorzata
Cognome: Kielbasa
Email: send email
Telefono: 4420310000000
Fax: 442078000000

UK (LONDON) coordinator 231˙283.20

Mappa

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 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

brain    techniques    neurons    questions    primary    potentials    code    sensory    me    cortex    stimulus    world    manipulate    precision    behaviorally    resolution    touch    neural    cortices    single    action   

 Obiettivo del progetto (Objective)

'How do neurons in the brain process information from the outside world? Although generations of neuroscientists have focused on this question, it remains a mystery. The crux of the problem is to understand the neural code, or the rubric by which the brain converts information about the world into brain activity. Primary sensory cortices, where much of the transformation of information takes place, contain many different types of neurons embedded in dense networks, making it difficult to follow the flow of information. However, recent advances in optical techniques have drastically improved the precision with which neural activity can be recorded and stimulated, achieving fine-scale resolution of single action potentials in individual neurons across a population of many neurons. I propose to manipulate action potential sequences in the cortex of an awake behaving animal, which will elucidate facets of the neural code in a quantitative and direct manner. By training a mouse to behaviorally respond to whisker stimulation and recording the activity of the neurons in somatosensory cortex, I will uncover the specific neurons coding the stimulus. Then I will manipulate the activity of those neurons by combining the temporal precision of optogenetics with the spatial resolution of advanced two-photon microscopy. These techniques will allow me to activate single action potentials in individually selected neurons in three dimensions for the first time, which will allow me to explore the neural code quantitatively. Crucial questions that this proposal seeks to answer are: How many spikes in how many neurons that are behaviorally relevant to a stimulus are sufficient to generate a percept? How robust to noise is the neural code for touch? How important is timing to the neural code for touch? Answers to these questions will allow us to better understand some of the basic features of the neural code in primary sensory cortices, a major goal in neuroscience.'

Altri progetti dello stesso programma (FP7-PEOPLE)

WORMPROLOC (2012)

"The subnuclear relocation of promoters during development, and following stress induction in C. elegans"

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POPCODE (2010)

Statistical methods for modelling population activity in visual cortex

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ISOCIAL (2012)

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