E-WALK

Spinal cord rehabilitation enhanced by the use of data-driven and dynamic cortical state models

Coordinatore	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE    more  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Grégoire Cognome: Courtine Email: send email Telefono: +41 21 693 83 43 Fax: +41 21 693 72 95
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	192˙622 €
EC contributo	192˙622 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IIF
Funding Scheme	MC-IIF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-05-01   -   2015-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Grégoire Cognome: Courtine Email: send email Telefono: +41 21 693 83 43 Fax: +41 21 693 72 95	CH (LAUSANNE)	coordinator	192˙622.20

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 Obiettivo del progetto (Objective)

'Neuromotor disease and insult negatively affect the lives of millions of people worldwide. In some cases, such as severe spinal cord injury (SCI), a completely functional central nervous system is abruptly disconnected from the completely functional body. Currently, there is no therapy capable of promoting recovery after complete spinal cord injury. While our understanding of the organization of the brain has advanced dramatically in recent years, there have been few successes building a complete system to enable people in such states to regain the ability to interact with and control their environment. Two clinical approaches to treatment have been used: one where brain scientists and engineers have developed cortical implants to record and decode the intended movement for prosthetic control, and one where robotic assisted rehabilitation of the damaged area is driven by coordinated electrochemical stimulation. These two neural interface technologies paint the background of the proposed research. Expertise in the design of brain machine interfaces combined with the advanced spinal neuroprosthesis developed in the host laboratory open the intriguing possibility to merge both approaches, and pioneer a brain spinal interface (BSI) system capable of restoring movement in severely paralyzed subjects. Consequently, this project addresses two critical and clinically applicable hypotheses for the fusion of population decoding in the brain and electrochemical stimulation of the spinal cord after complete or partial SCI. First, after complete SCI, a BSI may re-establish cortical control over a library of spinal cord stimulation paradigms, thus restoring a range of voluntary locomotor functions in paralyzed rats. Second, training enabled by a newly developed BSI in rats with a severe spinal cord contusion may enhance remodeling of supraspinal and spinal neural systems, thus leading to significantly improved recovery compared to training with electrochemical stimulation alone.'

Introduzione (Teaser)

Currently, no therapy is capable of promoting recovery after complete spinal cord injury (SCI). European scientists developed a brain-spinal interface (BSI) system with a goal to restore movement in severely paralysed subjects.