GUTENCODE

Decoding the transcriptional networks controlling the adult Drosophila midgut compartmentalization

Coordinatore	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE    more  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Bruno Cognome: Lemaitre Email: send email Telefono: +41 21 693 18 31 Fax: +41 21 693 17 90
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	184˙709 €
EC contributo	184˙709 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IEF
Funding Scheme	MC-IEF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-05-01   -   2015-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Bruno Cognome: Lemaitre Email: send email Telefono: +41 21 693 18 31 Fax: +41 21 693 17 90	CH (LAUSANNE)	coordinator	184˙709.40

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 Obiettivo del progetto (Objective)

'In recent years, the contribution of gut to health and disease, as well as the mechanisms important for gut homeostasis, like the maintenance of intestinal stem cells, have just began to be unraveled. Due to its general importance, studies addressing intestinal organization and physiology and, more generally, the question of how this organ functions as a whole, will become one of the most promising areas of research. In all animals, the mature gut is characterized by a succession of distinct compartments, which all fulfil important physiological function. However, how gut compartmentalization and the specialization of the different regions are controlled is largely unsolved in both Drosophila and mammals. The host lab has recently defined different sub-domains of the adult Drosophila midgut using both morphological and genetic criteria. This proposal aims to further unravel gene regulatory networks that control formation and function of each compartment, using a combination of state-of-the-art genetic, genomic, molecular and computational approaches. First, cis-regulatory elements (CREs) specific for different gut compartments will be systematically identified using ChIP-seq; second, key transcription factors interacting with compartment-specific CREs will be elucidated by yeast one-hybrid screens; third, the function of key transcriptional regulators in gut formation and maintenance, in particular the HOX transcription factors, will be studied using molecular, biochemical and genetic tools; and finally, I will apply computational tools to globally predict compartment-specific CREs based on the co-occupancy of key transcription factors identified above. This study will significantly advance our understanding of the mechanisms underlying the gut function, and will also have a major impact on understanding regulatory programs crucial for proper gut function in mammals.'