ORIENTATION

Orientation and disorientation in health and disease

Coordinatore	HADASSAH MEDICAL ORGANIZATION    more  Organization address address: n/a city: JERUSALEM postcode: 91120 contact info Titolo: Dr. Nome: Hadas Cognome: Lemberg Email: send email Telefono: +972 2 6776095 Fax: +972 2 6434701
Nazionalità Coordinatore	Israel [IL]
Totale costo	164˙378 €
EC contributo	164˙378 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IEF
Funding Scheme	MC-IEF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-06-01   -   2015-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	HADASSAH MEDICAL ORGANIZATION  Organization address address: n/a city: JERUSALEM postcode: 91120 contact info Titolo: Dr. Nome: Hadas Cognome: Lemberg Email: send email Telefono: +972 2 6776095 Fax: +972 2 6434701	IL (JERUSALEM)	coordinator	164˙378.40

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 Obiettivo del progetto (Objective)

'Orientation in space, time, and person is the essence of the behaving self, and the bedrock of neurological and psychiatric mental status examination. States of disorientation may be the hallmark manifestation of several neuropsychiatric disorders. Despite orientation’s central role in health and disease, orientation has almost never been a subject for neuroscientific research. Consequently, there is uncertainty as to the cognitive and clinical meaning of orientation, and its role in the psychopathology of several major neuropsychiatric disorders, such as dissociative disorders, misidentification syndromes, or Alzheimer’s disease and amnesia syndromes. Here we hypothesize that (1) orientation is a distinct cognitive function and that (2) orientations over the different domains and clinical conditions rely on shared psychological and neural mechanisms. We propose to investigate the ability of humans to orient themselves in time, space and person, based on a unified referential system. We will examine whether orientations in the different domains are placed on a common vectorial trajectory, using mental tasks, functional imaging (with new analyses methods as based on machine learning and networks research) and computational neuroscience in healthy individuals and those affected by disorders of disorientation. While presently we do not have any established definition of the role of orientation in central pathologies our results might therefore define the orientation system and its role in neuropsychiatric disorders in which orientation is disturbed. This may be important for the recent challenge of our orientation system by the cyber world, which changes our habitual relations to space, time, and people. Finally, the study results will be used in order to established neuroimaging based tools for diagnosis, monitoring and management of disorientation disorders such as Alzheimer’s disease and dissociative disorders.'