ASKLEPIOS
Advanced Studies towards Knowledge on Lyssavirus Encephalitis Pathogenesis Improving Options for Survival
| Coordinatore | ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address
address: 's Gravendijkwal 230 contact info |
| Nazionalità Coordinatore | Netherlands [NL] |
| Totale costo | 4˙072˙356 € |
| EC contributo | 2˙994˙881 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2013-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-11-01 - 2016-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address
address: 's Gravendijkwal 230 contact info |
NL (ROTTERDAM) | coordinator | 706˙679.00 |
| 2 |
VYZKUMNY USTAV VETERINARNIHO LEKARSTVI
Organization address
address: Hudcova 70 contact info |
CZ (BRNO) | participant | 482˙506.00 |
| 3 |
THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS
Organization address
address: Area 1A, Nobel House, Smith Square 17 contact info |
UK (LONDON) | participant | 470˙057.00 |
| 4 |
PANSTWOWY INSTYTUT WETERYNARYJNY - PANSTWOWY INSTYTUT BADAWCZY
Organization address
address: Partyzantow 57 contact info |
PL (PULAWY) | participant | 428˙299.00 |
| 5 |
ARTEMIS ONE HEALTH RESEARCH BV
Organization address
address: JENALAN 18C contact info |
NL (UTRECHT) | participant | 347˙360.00 |
| 6 |
SZENT ISTVAN UNIVERSITY
Organization address
address: Pater Karoly utca 1 contact info |
HU (GODOLLO) | participant | 240˙000.00 |
| 7 |
MAGYAR TUDOMANYOS AKADEMIA AGRARTUDOMANYI KUTATOKOZPONT
Organization address
address: BRUNSZVIK STREET 2 contact info |
HU (MARTONVASAR) | participant | 239˙940.00 |
| 8 |
KATHOLIEKE UNIVERSITEIT LEUVEN
Organization address
address: Oude Markt 13 contact info |
BE (LEUVEN) | participant | 59˙040.00 |
| 9 |
INSTITUT PASTEUR
Organization address
address: RUE DU DOCTEUR ROUX 25-28 contact info |
FR (PARIS CEDEX 15) | participant | 21˙000.00 |
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Obiettivo del progetto (Objective)
'The overall aim of ASKLEPIOS is to unravel and increase our understanding of the mechanisms that govern pathogenesis of rabies virus (RABV) infection, in pursuit of the rational identification of novel therapeutic leads for rabies encephalitis. Several studies have been conducted over the past decades attempting to unravel the pathogenesis of this deadly disease, however with limited success. New knowledge on the mechanisms of the RABV life-cycle and interaction with the host is needed to identifying clinically applicable therapeutic leads, in search of rational intervention strategies. The project objectives are to: 1. Identify molecules that inhibit RABV replication 2. Identify molecules that inhibit detrimental host responses to RABV infection: 3. Show whether opening the blood-brain-barrier (BBB) improves treatment efficacy: 4. Validate the potential of the molecules identified under 1 and 2 to be used as post-exposure prophylaxis (PEP) when classical PEP is ineffective. In pursuit of these objectives ASKLEPIOS will perform in vitro screening of the anti-viral effect of type-I IFNs, MAP kinase inhibitors and siRNAs. Second, the therapeutic potential of inhibiting the pyroptotic pathway and inflammatory response will be investigated by using inhibitors of caspase-1, IL-1β, TNF-α IL-6 and MAP kinases. Third, the capacity of molecules to reach the brain will be first evaluated using an efficient in vitro BBB system and in vivo mouse studies.. The most efficient molecule to open the BBB will be co-administrated with the selected therapeutic molecules in the subsequent stages of the project. The results will be collected and synthesized and tested in mice to identify the most effective approach. The ability to clear infection and recover from rabies will be evaluated for each therapeutic scheme identified'