REENGINEERINGCANCER

Re-engineering the tumor microenvironment to alleviate mechanical stresses and improve chemotherapy

Coordinatore	UNIVERSITY OF CYPRUS    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Cyprus [CY]
Totale costo	1˙440˙360 €
EC contributo	1˙440˙360 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2013-StG
Funding Scheme	ERC-SG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-01-01   -   2018-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF CYPRUS  Organization address address: KALLIPOLEOS STREET 75 city: NICOSIA postcode: 1678 contact info Titolo: Dr. Nome: Triantafyllos Cognome: Stylianopoulos Email: send email Telefono: 35722892238 Fax: 35722894472	CY (NICOSIA)	hostInstitution	1˙440˙360.00
2	UNIVERSITY OF CYPRUS  Organization address address: KALLIPOLEOS STREET 75 city: NICOSIA postcode: 1678 contact info Titolo: Mrs. Nome: Eliza Cognome: Archeou Email: send email Telefono: 35722894076	CY (NICOSIA)	hostInstitution	1˙440˙360.00

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 Obiettivo del progetto (Objective)

'Current chemotherapeutic agents are potent enough to kill cancer cells. Nonetheless, failure of chemotherapies for many cancers (e.g. breast and pancreatic cancers and various sarcomas) is primarily because these agents cannot reach cancer cells in amounts sufficient to cause complete cure. The abnormal microenvironment of these tumors drastically reduces perfusion and results in insufficient delivery of therapeutic agents. Tumor structural abnormalities is in large part an effect of mechanical stresses developed within the tumor due to unchecked cancer cell proliferation that strains the tumor microenvironment. Alleviation of these stresses has the potential to normalize the tumor, enhance delivery of drugs and improve treatment efficacy. Here, I propose to test the hypothesis that re-engineering the tumor microenvironment with stress-alleviating drugs has the potential to enhance chemotherapy. To explore this hypothesis, I will make use of a mixture of cutting-edge computational and experimental techniques. I will develop sophisticated models for the biomechanical response of tumors to analyze how stresses are generated and transmitted during tumor progression. Subsequently, I will perform animal studies to validate model predictions and indentify the drug that more effectively alleviates stress levels, normalizes the tumor microenvironment and improves chemotherapy. Successful completion of this research will reveal the mechanisms for stress generation and storage in tumors and will lead to new strategies for the use of chemotherapy.'