OPTIMEX

Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure

Coordinatore	NORGES TEKNISK-NATURVITENSKAPELIGEUNIVERSITET NTNU    more  Organization address address: HOGSKOLERINGEN 1 city: TRONDHEIM postcode: 7491 contact info Titolo: Prof. Nome: Ulrik Cognome: Wisløff Email: send email Telefono: +47 95883501
Nazionalità Coordinatore	Norway [NO]
Sito del progetto	http://www.ntnu.edu/optimex
Totale costo	3˙853˙084 €
EC contributo	2˙999˙995 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2013-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-10-01   -   2017-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	NORGES TEKNISK-NATURVITENSKAPELIGEUNIVERSITET NTNU  Organization address address: HOGSKOLERINGEN 1 city: TRONDHEIM postcode: 7491 contact info Titolo: Prof. Nome: Ulrik Cognome: Wisløff Email: send email Telefono: +47 95883501	NO (TRONDHEIM)	coordinator	1˙087˙161.00
2	UNIVERSITAET LEIPZIG  Organization address address: RITTERSTRASSE 26 city: LEIPZIG postcode: 4109 contact info Titolo: Dr. Nome: Volker Cognome: Adams Email: send email Telefono: +49 3418651671	DE (LEIPZIG)	participant	563˙460.00
3	KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN  Organization address address: ISMANINGER STRASSE 22 city: MUENCHEN postcode: 81675 contact info Titolo: Ms. Nome: Renate Cognome: Rädlein Email: send email Telefono: +49 89 4140 2842 Fax: +49 89 4140 4926	DE (MUENCHEN)	participant	456˙928.00
4	UNIVERSITAIR ZIEKENHUIS ANTWERPEN  Organization address address: WILRIJKSTRAAT 10 city: EDEGEM postcode: 2650 contact info Titolo: Prof. Nome: Viviane Cognome: Conraads Email: send email Telefono: +32 474900396	BE (EDEGEM)	participant	392˙815.60
5	Medizinische Universitaet Graz  Organization address address: AUENBRUGGERPLATZ 2 city: GRAZ postcode: 8036 contact info Titolo: Dr. Nome: Carolin Cognome: Auer Email: send email Telefono: +0043 31638572016 Fax: 4331640000000	AT (GRAZ)	participant	371˙223.60
6	Vitaphone GmbH  Organization address address: Markircher Strasse 22 city: Mannheim postcode: 68229 contact info Titolo: Mr. Nome: Walter Cognome: Schmid Email: send email Telefono: +49 621178918100	DE (Mannheim)	participant	128˙407.50

Mappa

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 Obiettivo del progetto (Objective)

'More than 14 million Europeans suffer from heart failure (HF), of which more than 50 % have HF with preserved left ventricular (LV) ejection fraction (EF) (HFPEF, “diastolic heart failure”). HFPEF is the only cardiovascular disease with increasing prevalence and incidence, affecting 10-20% of the elderly and contributing substantially to hospitalizations of elderly HF patients. Currently, no medical treatment has been shown to be effective and the economic, social and personal burden of HFPEF is enormous; this disease constitutes one of the most pressing unmet clinical needs. A cardinal feature of HFPEF is exercise intolerance. The pathophysiology of exercise intolerance in HFPEF depends on multiple factors in heart, endothelium and skeletal muscles. From a pathophysiological point of view, exercise could by far outweigh any pharmacological intervention in this heterogeneous syndrome, since lifestyle dependent risk factor, physical inactivity, and physical deconditioning underlay and contribute to HFPEF. OptimEx will focus on the cardiovascular effects of exercise training as primary and secondary prevention of HFPEF. We will combine in vivo and in vitro studies in man and rats in serial experiments that will advance our understanding of fundamental cellular and molecular mechanisms underpinning dose-dependent exercise-induced changes in the heart, blood vessels and skeletal muscles. This research is aimed to tackle one of the major health problems the developed world faces with its ageing societies and increasing prevalence of the HFPEF and will support sustainable health systems in EU member states through improvements in the clinical management of a common and disabling disease. The project is therefore highly relevant to improve the health of European citizens and important to promote healthy ageing and preventing disease.'