PAIN-OMICS
Multi-dimensional omics approach to stratification of patients with low back pain
| Coordinatore | UNIVERSITA DEGLI STUDI DI PARMA
Organization address
address: VIA UNIVERSITA 12 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Totale costo | 8˙576˙693 € |
| EC contributo | 5˙998˙886 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2013-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-09-01 - 2018-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITA DEGLI STUDI DI PARMA
Organization address
address: VIA UNIVERSITA 12 contact info |
IT (PARMA) | coordinator | 1˙156˙980.00 |
| 2 |
GENOS DOO ZA VJESTACENJE I ANALIZU
Organization address
address: Vatrogasna 112 contact info |
HR (Osijek) | participant | 990˙300.00 |
| 3 |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Organization address
address: Ingolstaedter Landstrasse 1 contact info |
DE (MUENCHEN) | participant | 750˙364.00 |
| 4 |
"SPECIJALNA BOLNICA ZA ORTOPEDIJU, KIRURGIJU, NEUROLOGIJU I FIZIKALNU MEDICINU I REHABILITACIJU SVETA KATARINA USTANOVA"
Organization address
address: BRACAK 8 contact info |
HR (ZABOK) | participant | 669˙300.00 |
| 5 |
THE CENTER FOR CLINICAL RESEARCH LLC
Organization address
address: KIMEL PARK DRIVE 145 SUITE 330 contact info |
US (WINSTON SALEM) | participant | 581˙020.00 |
| 6 |
KING'S COLLEGE LONDON
Organization address
address: Strand contact info |
UK (LONDON) | participant | 524˙124.00 |
| 7 |
IP RESEARCH CONSULTING SASU
Organization address
address: QUAI DES DEUX PONTS 31 contact info |
FR (NOISY LE GRAND) | participant | 359˙900.00 |
| 8 |
AULCHENKO YURY SERGEYEVICH
Organization address
address: DE SAVORNIN LOHMANLAAN 19 A contact info |
NL (GRONINGEN) | participant | 324˙498.00 |
| 9 |
ZIEKENHUIS OOST-LIMBURG AUTONOME VERZORGINGSINSTELLING
Organization address
address: SCHIEPSE BOS 6 contact info |
BE (GENK) | participant | 322˙400.00 |
| 10 |
FONDAZIONE IRCCS POLICLINICO SAN MATTEO
Organization address
address: VIALE GOLGI 19 contact info |
IT (PAVIA) | participant | 320˙000.00 |
| 11 |
Edith Cowan University
Organization address
address: Joondalup Drive 270 contact info |
AU (Joondalup) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Pain-OMICS is a multidisciplinary consortium of leading clinical, academic and SME researchers in pain and different omics technologies. Genome-wide association studies identified a number of loci associated with pain, but the level of knowledge about underlying mechanisms of different pain syndromes as well as individual variation in the disease course remains inadequate. Pain-OMICS will capitalise on its existing high quality clinical, genetic, biochemical and pharmacological data and biological samples on over 5000 well characterised patients with low-back pain (LBP) and controls available to our EU and US clinical partners. We will exploit novel technological approaches made available through the expertise and global leading position of our analytical partners. These comprise cutting edge genomic, epigenomic, glycomic, and activomic approaches which reflect signal transduction and membrane dynamics. We believe that the inclusion of these complementary analyses will elucidate pathways through which acute LBP fails to resolve and becomes chronic LBP. In addition, these approaches will reveal pathways and biomarkers of chronic pain through which individual differences affects symptoms and response to therapy. Participation of leading clinics on both sides of the Atlantic will enable replication of all finding in at least three independent large cohorts, as well as in prospective study and a large twin cohort. A complex systems biology approach will be used to integrate, interrogate and understand this multidimensional dataset in order to achieve the aims of identifying novel diagnostic and prognostic biomarkers as well as new targets for therapeutic intervention. The track record of achievement of our partners coupled to participation of research-intensive SMEs is a strong indication that the ambitious work programme will be achieved and provides a framework for rapid translation of research discoveries into solutions for the benefit of large numbers of patients.'
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